Now showing items 11-20 of 37
Preoperative idoxuridine and radiation for large soft tissue sarcomas: Clinical results with five-year follow-up
(Springer-Verlag; The Society of Surgical Oncology, Inc., 1998-03)
Background: Local control remains an important issue in the management of large soft tissue sarcomas. Radiation is the main adjuvant to surgery for local therapy of sarcomas, but it requires relatively high doses, hitherto ...
Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
(Kluwer Academic Publishers; Springer, 2005-08)
To prospectively compare the ability of clinical examination, mammography, vascularity-sensitive ultrasound, and magnetic resonance imaging (MRI) to determine pathologic complete response (CR) in breast cancer patients ...
Frequency, nature, effects, and correlates of conflicts of interest in published clinical cancer research
(Wiley Subscription Services, Inc., A Wiley Company, 2009-06-15)
BACKGROUND: Relationships between clinical researchers and industry are becoming increasingly complex. The frequency and impact of conflicts of interest in the full range of high-impact, published clinical cancer research ...
Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner
(John Wiley & Sons, Inc., 2000-04)
Matrix metalloproteinases (MMPs) are a family of proteinases that degrade the basement membrane and have been implicated in promoting tumor metastasis. MMP-2, one member of this family, was recently found to be a p53 target ...
Mitotic Rate and Younger Age Are Predictors of Sentinel Lymph Node Positivity: Lessons Learned From the Generation of a Probabilistic Model
(Springer-Verlag; The Society of Surgical Oncology, Inc., 2004-03)
Background: Sentinel lymph node (SLN) biopsy allows surgeons to identify patients with subclinical nodal involvement who may benefit from lymphadenectomy and, possibly, adjuvant therapy. Several factors have been variably, ...
Promoter hypermethylation of CDH13 is a common, early event in human esophageal adenocarcinogenesis and correlates with clinical risk factors
(Wiley Subscription Services, Inc., A Wiley Company, 2008-11-15)
Although the CDH13 gene has been shown to undergo epigenetic silencing by promoter methylation in many types of tumors, hypermethylation of this gene in Barrett's-associated esophageal adenocarcinogenesis has not been ...
Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology
(John Wiley & Sons, Inc., 1999-02)
Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and ...
Interleukin-6 predicts recurrence and survival among head and neck cancer patients See editorial on pages 671–3, this issue.
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-15)
BACKGROUND. Increased pretreatment serum interleukin (IL)-6 levels among patients with head and neck squamous cell carcinoma (HNSCC) have been shown to correlate with poor prognosis, but sample sizes in prior studies have ...
p53 and its downstream proteins as molecular targets of cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2006-06)
The p53 tumor suppressor gene plays a key role in prevention of tumor formation through transcriptional dependent and independent mechanisms. Transcriptional-dependent mechanisms are mainly mediated by p53 regulation of ...
The conservative management of Paget's disease of the breast with radiotherapy Presented in part at the 38th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Los Angeles, California, October 27-30, 1996.
(John Wiley & Sons, Inc., 1997-09-15)
BACKGROUND The purpose of this study was to evaluate the feasibility of breast-conserving therapy involving limited surgery and definitive radiotherapy as a treatment for Paget's disease, and to determine the disease free ...