Now showing items 21-30 of 39
Gamma-irradiation induces matrix metalloproteinase II expression in a p53-dependent manner
(John Wiley & Sons, Inc., 2000-04)
Matrix metalloproteinases (MMPs) are a family of proteinases that degrade the basement membrane and have been implicated in promoting tumor metastasis. MMP-2, one member of this family, was recently found to be a p53 target ...
Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology
(John Wiley & Sons, Inc., 1999-02)
Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and ...
Interleukin-6 predicts recurrence and survival among head and neck cancer patients See editorial on pages 671–3, this issue.
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-15)
BACKGROUND. Increased pretreatment serum interleukin (IL)-6 levels among patients with head and neck squamous cell carcinoma (HNSCC) have been shown to correlate with poor prognosis, but sample sizes in prior studies have ...
p53 and its downstream proteins as molecular targets of cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2006-06)
The p53 tumor suppressor gene plays a key role in prevention of tumor formation through transcriptional dependent and independent mechanisms. Transcriptional-dependent mechanisms are mainly mediated by p53 regulation of ...
The conservative management of Paget's disease of the breast with radiotherapy Presented in part at the 38th Annual Meeting of the American Society for Therapeutic Radiology and Oncology, Los Angeles, California, October 27-30, 1996.
(John Wiley & Sons, Inc., 1997-09-15)
BACKGROUND The purpose of this study was to evaluate the feasibility of breast-conserving therapy involving limited surgery and definitive radiotherapy as a treatment for Paget's disease, and to determine the disease free ...
Toxicity of radiotherapy in patients with collagen vascular disease
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-01)
BACKGROUND. A diagnosis of collagen vascular disease (CVD) may predispose to radiotherapy (RT) toxicity. The objective of the current study was to identify factors that influence RT toxicity in the setting of CVD. METHODS. ...
Treatment choices and response rates in African-American women with breast carcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2003-01-01)
BACKGROUND Breast cancer mortality rates are higher among African-American women compared with white American women, yet little is known regarding ethnicity-related variation in patterns of primary surgical treatment, ...
Under-representation of women in high-impact published clinical cancer research
(Wiley Subscription Services, Inc., A Wiley Company, 2009-07-15)
BACKGROUND. Adequate representation of women in research has been deemed essential. METHODS. Cancer research published in 8 journals in 2006 was reviewed. The percentage of women among study participants was compared ...
On the development of gemcitabine-based chemoradiotherapy regimens in pancreatic cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2002-08-15)
The use of chemotherapy with concurrent radiation therapy remains a standard treatment option for patients with unresectable or resected adenocarcinoma of the pancreas. This treatment strategy is based in large part on ...
Conservative management of Paget disease of the breast with radiotherapy
(Wiley Subscription Services, Inc., A Wiley Company, 2003-05-01)
BACKGROUND At 5-year follow-up, patients with Paget disease of the breast who were treated with breast-conserving surgery (BCS) and radiotherapy (RT) had excellent results. The current report provides 10- and 15-year rates ...