Now showing items 61-67 of 67
A Measure of the Proportion of Treatment Effect Explained by a Surrogate Marker
(Blackwell Publishing Ltd, 2002-12)
Randomized clinical trials with rare primary endpoints or long duration times are costly. Because of this, there has been increasing interest in replacing the true endpoint with an earlier measured marker. However, surrogate ...
Nonparametric comparison of two survival functions with dependent censoring via nonparametric multiple imputation
(John Wiley & Sons, Ltd., 2009-02-01)
When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation ...
Dissimilar actions of 6-mercaptopurine and 6-thioguanine in Chinese hamster ovary cells
(Elsevier, 1985-10-15)
The actions of 6-thioguanine (TG) and 6-mercaptopurine (MP) were compared in Chinese hamster ovary (CHO) cells. Several differences were noted between these two agents. TG caused a greater maximal loss of clonogenicity, ...
T cell receptor [beta]-chain gene rearrangement without [gamma]-chain gene rearrangement in cutaneous T cell lymphoma: An unusual finding
(Elsevier, 1990-03)
T cells from the blood and skin of a patient with cutaneous T cell lymphoma demonstrated rearrangement of the T cell receptor [beta]-chain gene in the absence of rearrangement of the [gamma]-chain gene. To our knowledge, ...
Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples
(WILEY-VCH Verlag, 2006-09)
A unique approach of automating the integration of monolithic capillary HPLC-based protein separation and on-plate digestion for subsequent MALDI-MS analysis has been developed. All liquid-handling procedures were performed ...
Estimation in a Cox Proportional Hazards Cure Model
(Blackwell Publishing Ltd, 2000-03)
Some failure time data come from a population that consists of some subjects who are susceptible to and others who are nonsusceptible to the event of interest. The data typically have heavy censoring at the end of the ...
Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization
(Springer-Verlag, 1992-07)
Two highly conserved forms of cellular retinoic acid binding protein (CRABP-I and CRABP-II) have been described, and one, CRABP-II, is highly expressed in human skin. We have utilized a 10-kb fragment containing the human ...