Now showing items 1-10 of 32
Effect of p53 overexpression on radiation sensitivity of human colon cancer cells
(John Wiley & Sons, Inc., 1997)
Substantial controversy surrounds our understanding of the effect of p53 status on radiation sensitivity. To assess directly the role of p53 expression on radiation sensitivity, we chose a conditional expression system ...
Interleukin-6 in psoriasis: expression and mitogenicity studies
(Springer-Verlag, 1992-12)
InterIeukin-6 (IL-6) is a multifunctional cytokine which has been suggested to function as an autocrine mitogen in psoriatic epidermis. We report here the results of several experiments designed to further examine this ...
Induction of glutathione S -transferase-Π in Barrett's metaplasia and Barrett's adenocarcinoma cell lines
(John Wiley & Sons, Inc., 1999-02)
Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for ...
Dosimetric comparison of bolus and continuous injections of CC49 monoclonal antibody in a colon cancer xenograft model Presented at the Sixth Conference on Radioimmunodetection and Radioimmunotherapy of Cancer, Princeton, New Jersey, October 10-12, 1996.
(John Wiley & Sons, Inc., 1997-12-15)
BACKGROUND Improved understanding of dose and effective dose calculations may contribute to the optimization of fractionated radioimmunotherapy. METHODS Comparison three-dimensional tumor dosimetry was performed on ...
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
Purpose : We have reported previously that the expression of E. coli dUTPase (dutE) can protect HT29 cells from 5-fluorodeoxyuridine (FdUrd)-induced DNA fragmentation and cytotoxicity. In the study reported here, we further ...
Stereotactic Radiosurgery of a Patient with Severe Kyphosis
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-06)
A patient with a severe kyphotic deformity presented for stereotactic radiosurgery. In the supine position with the apex of the patient's kyphosis on the treatment couch, his head and buttocks were found to be approximately ...
Evaluation of the hairless rat as a model for in vivo percutaneous absorption
(John Wiley & Sons, Inc., 1997-01)
Percutaneous absorption of topically applied mannitol and progesterone was compared in vivo with the hairless and hairy rat. Urinary excretion and skin concentration profiles after topical application of mannitol demonstrated ...
Distal chromosome 17q loss in Barrett's esophageal and gastric cardia adenocarcinomas: Implications for tumorigenesis
(John Wiley & Sons, Inc., 1998-08)
The molecular genetic mechanisms underlying esophageal cancer are poorly understood. However, a novel gene that may be involved in esophageal carcinogenesis was recently localized by others to distal 17q by linkage analysis ...
Identification of altered growth phenotypes in human breast cancer cells using cell culture methods that support growth of normal and neoplastic mammary epithelial cells
(Wiley Subscription Services, Inc., A Wiley Company, 1993)
Over the past several years our laboratory has been studying factors that regulate proliferation of normal human mammary epithelial (HME) cells in order to better understand the alterations in cellular growth control ...
Finite proliferative lifespan in vitro of a human breast cancer cell strain isolated from a metastatic lymph node
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-01)
We recently described culture conditions that allow proliferation of metastatic human breast cancer cells from biopsy specimens of certain patient samples. These conditions resulted in the development of an immortalized ...