Now showing items 1-10 of 20
Mechanism and pharmacological specificity of dUTPase-mediated protection from DNA damage and cytotoxicity in human tumor cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1998-09)
Purpose : We have reported previously that the expression of E. coli dUTPase (dutE) can protect HT29 cells from 5-fluorodeoxyuridine (FdUrd)-induced DNA fragmentation and cytotoxicity. In the study reported here, we further ...
Highly Efficient, Near-Infrared Electrophosphorescence from a Pt–Metalloporphyrin Complex The authors acknowledge financial support from the U.S. Dept. of the Army, CECOM for the phase 14II SBIR program (contract no. 14W15P7T-06-C-T201), and Universal Display Corporation.
(WILEY-VCH Verlag, 2007-02-05)
No Abstract
Assessment of skin dose for breast chest wall radiotherapy as a function of bolus material
(2008)
"Skin dose assessment for chest wall radiotherapy is important to ensure sufficient dose to the surface target volume without excessive skin reaction. This study quantified changes to the surface doses as a function of ...
Evaluation of ( E )-2′-deoxy-2′-(fluoromethylene)cytidine on the 9L rat brain tumor model using MRI
(John Wiley & Sons, Ltd., 2003-04)
( E )-2′-deoxy-2′-(fluoromethylene)cytidine (FMdC), was evaluated as a potential treatment for malignant gliomas using the rat 9L brain tumor model. FMdC was shown to be an effective inhibitor of cell proliferation in ...
The role of p53 in gemcitabine-mediated cytotoxicity and radiosensitization
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-04)
Purpose : We compared the cytotoxic and radiosensitizing effects of gemcitabine (2′,2′-difluoro-2′-deoxycytidine, dFdCyd), a clinically valuable radiosensitizer, in colon cancer RKO cells which differed in their p53 status. ...
Dependence of fluorodeoxyuridine-induced cytotoxicity and megabase DNA fragment formation on S phase progression in HT29 cells
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 1996-02)
The relationship between cell cycle progression and induction of DNA double-strand breaks and cytotoxicity by exposure to fluorodeoxyuridine (FdUrd) was studied in HT29 human colon cancer cells. Fractionation of drug-treated ...
Simultaneous determination of thymine and 5-bromouracil in DNA hydrolysates using gas chromatography--mass spectrometry with selected-ion monitoring
(Elsevier, 1986)
The gas chromatographic--mass spectrometric method using selected-ion monitoring (GC--MS--SIM) described here quantitatively determines the amount of DNA thymine replacement by 5-bromouracil (BU) after exposure to ...
Analysis of bromodeoxyuridine incorporation into DNA: Comparison of gas chromatographic/mass spectrometric, CsCl gradient sedimentation, and specific radioactivity methods
(Elsevier, 1987-02-15)
A sensitive new method for the quantitation of 5-bromodeoxyuridine (BrdUrd) incorporated into DNA by GC/MS analysis of enzymatically released Thy and bromouracil (BrUra) is presented. The hydrolysis procedure was characterized ...
Interaction between gemcitabine and mitomycin-C in vitro
(Springer-Verlag; Springer-Verlag Berlin Heidelberg, 2000-01)
Both gemcitabine (2′,2′-difluorodeoxycytidine; dFdCyd) and mitomycin-C (MMC) are active against several solid malignancies. dFdCyd is an attractive agent for use in combination with drugs which damage DNA and with radiation ...
Proton and sodium MRI assessment of emerging tumor chemotherapeutic resistance
(John Wiley & Sons, Ltd., 2006-12)
The ultimate goal of any cancer therapy is to target the elimination of neoplastic cells. Although newer therapeutic strategies are in constant development, therapeutic assessment has been hampered by the inability to ...