Now showing items 1-8 of 8
Modeling intra-tumor protein expression heterogeneity in tissue microarray experiments
(John Wiley & Sons, Ltd., 2008-05-20)
Tissue microarrays (TMAs) measure tumor-specific protein expression via high-density immunohistochemical staining assays. They provide a proteomic platform for validating cancer biomarkers emerging from large-scale DNA ...
Analysis on binary responses with ordered covariates and missing data
(John Wiley & Sons, Ltd., 2007-08-15)
We consider the situation of two ordered categorical variables and a binary outcome variable, where one or both of the categorical variables may have missing values. The goal is to estimate the probability of response of ...
Estimation for paired binomial data with application to radiation therapy
(John Wiley & Sons, Ltd., 2001-11-30)
We compare and contrast several different methods for estimating the effect of treatment when responses are paired binomial observations. The ratio of binomial probabilities is the parameter of interest, while the binomial ...
Early NFΚB activation is inhibited during focal cerebral ischemia in interleukin-1Β-converting enzyme deficient mice
(Wiley Subscription Services, Inc., A Wiley Company, 2003-09-01)
Our previous study demonstrated that the inhibition of interleukin-1Β (IL-1Β) reduces ischemic brain injury; however, the molecular mechanism of the action of IL-1 in cerebral ischemia is unclear. We are investigating ...
A penalized likelihood approach for mixture cure models
(John Wiley & Sons, Ltd., 2009-02-01)
Cure models have been developed to analyze failure time data with a cured fraction. For such data, standard survival models are usually not appropriate because they do not account for the possibility of cure. Mixture cure ...
Multiple imputation for interval censored data with auxiliary variables
(John Wiley & Sons, Ltd., 2007-02-20)
We propose a non-parametric multiple imputation scheme, NPMLE imputation, for the analysis of interval censored survival data. Features of the method are that it converts interval-censored data problems to complete data ...
Bayesian generalized monotonic functional mixed models for the effects of radiation dose histograms on normal tissue complications
(John Wiley & Sons, Ltd., 2007-11-10)
When treating cancer patients with radiation therapy, the normal tissue in an organ close to the tumour usually receives some dose of radiation. The dose is not of the same intensity throughout the organ. This radiation ...
Nonparametric comparison of two survival functions with dependent censoring via nonparametric multiple imputation
(John Wiley & Sons, Ltd., 2009-02-01)
When the event time of interest depends on the censoring time, conventional two-sample test methods, such as the log-rank and Wilcoxon tests, can produce an invalid test result. We extend our previous work on estimation ...