Now showing items 21-30 of 174
Semiparametric Bayesian modeling of random genetic effects in family-based association studies
(John Wiley & Sons, Ltd., 2009-01-15)
We consider the inference problem of estimating covariate and genetic effects in a family-based case-control study where families are ascertained on the basis of the number of cases within the family. However, our interest ...
Understanding Potential Intraoperative Impediments for Learning Laparoscopic Nephrectomy
(Mary Ann Liebert, Inc., publishers, 2009-07-10)
Purpose: We evaluated factors that impact the ability to learn hand-assisted laparoscopic donor nephrectomy (HALDN) to identify impediments to diffusion of this procedure. Methods: From February 2002 to June 2004, we ...
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
(Wiley Subscription Services, Inc., A Wiley Company, 2003-06-01)
Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead ...
Decreased galectin-3 expression in prostate cancer
(John Wiley & Sons, Inc., 2000-07-01)
BACKGROUND Galectin-3 is a carbohydrate-binding protein whose level of expression has been shown to be correlated with metastatic potential in a number of different tumor types. The purpose of this investigation was to ...
Effects of examination technique modifications on pelvic organ prolapse quantification (POP-Q) results
(Springer-Verlag; International Urogynecological Association, 2003-06)
The pelvic organ prolapse quantification system (POP-Q) is currently the most quantitative, site-specific system for describing pelvic organ prolapse. To ensure that anatomic outcomes can be optimally assessed, investigators ...
Use of quality indicators to evaluate the care of patients with localized prostate carcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2003-03-15)
BACKGROUND The goal of quality assurance in health care is to preserve and improve patient care. Recently, RAND developed a set of evidence-based candidate indicators for evaluating the quality of care for patients with ...
Truncated E-cadherin potentiates cell death in prostate epithelial cells
(Wiley Subscription Services, Inc., A Wiley Company, 2005-05-15)
BACKGROUND E-cadherin, a fundamental component of the adherens junction, is known to mediate aggregation-dependent cell survival. We have previously identified a novel, calpain-dependent proteolytic cleavage of E-cadherin ...
The discovery and application of gene fusions in prostate cancer
(Blackwell Publishing Ltd, 2008-08)
Phase 1/2 dose-escalation study of a GM-CSF-secreting, allogeneic, cellular immunotherapy for metastatic hormone-refractory prostate cancer All patients provided informed consent.
(Wiley Subscription Services, Inc., A Wiley Company, 2008-09-01)
BACKGROUND This open-label, multicenter, dose-escalation study evaluated multiple dose levels of immunotherapy in patients with metastatic hormone-refractory prostate cancer (HRPC). The immunotherapy, based on the GVAX ...
Analysis of the gene coding for the BRCA2-Interacting protein PALB2 in hereditary prostate cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05-01)
BACKGROUND The genetic basis of susceptibility to prostate cancer (PRCA) remains elusive. Mutations in BRCA2 have been associated with increased prostate cancer risk and account for around 2% of young onset (<56 years) ...