Now showing items 71-80 of 174
PTHrP-induced MCP-1 production by human bone marrow endothelial cells and osteoblasts promotes osteoclast differentiation and prostate cancer cell proliferation and invasion in vitro
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-15)
Prostate cancer (PCa) preferentially metastasizes to bone resulting in osteoblastic lesions with underlying osteolytic activities. The mechanisms through which PCa cells promote osteolytic activities and subsequent ...
Bayesian inference for the stereotype regression model: Application to a case–control study of prostate cancer
(John Wiley & Sons, Ltd., 2009-11-10)
The stereotype regression model for categorical outcomes, proposed by Anderson ( J. Roy. Statist. Soc. B. 1984; 46 :1–30) is nested between the baseline-category logits and adjacent category logits model with proportional ...
Moving beyond the “1 size fits all” paradigm See referenced original article in Cancer . 2008;112:61–68.
(Wiley Subscription Services, Inc., A Wiley Company, 2008-03)
No abstract.
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
Expression and activation of Α v Β 3 integrins by SDF-1/CXC12 increases the aggressiveness of prostate cancer cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-01-01)
BACKGROUND Stromal cell-derived factor-1 (SDF-1 or CXCL12) and CXCR4 are key elements in the metastasis of prostate cancer cells to bone—but the mechanisms as to how it localizes to the marrow remains unclear. METHODS ...
PAR1-mediated NFΚB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
We have previously reported that protease-activated receptor 1 (PAR1 or thrombin receptor) is over-expressed in metastatic prostate cancer cell lines compared to prostate epithelial cells. In this study, we examined 1,074 ...
Pilot and feasibility study of serum chemokines as markers to distinguish prostatic disease in men with low total serum PSA
(Wiley Subscription Services, Inc., A Wiley Company, 2008-03-01)
BACKGROUND The incidence and prevalence of both benign prostatic hypertrophy (BPH) and prostate cancer (PCa) increase with the aging process. Our laboratory recently showed that the chemokines CXCL5 and CXCL12, which ...
Vorinostat in advanced prostate cancer patients progressing on prior chemotherapy (National Cancer Institute Trial 6862)
(Wiley Subscription Services, Inc., A Wiley Company, 2009-12-01)
BACKGROUND: This phase 2 trial was designed to evaluate the efficacy of vorinostat in chemotherapy-pretreated patients with metastatic castration-resistant prostate cancer. METHODS: Patients with disease progression on ...
Partially circumventing peripheral tolerance for oncogene-specific prostate cancer immunotherapy
(Wiley Subscription Services, Inc., A Wiley Company, 2008-05-15)
BACKGROUND Failure of cancer immunotherapy is essentially due to immunological tolerance to tumor-associated antigens (TAAs), as these antigens are also expressed in healthy tissues. METHODS Here, we used transgenic ...
OUTCOMES FOR RADIATION THERAPY AFTER RADICAL PROSTATECTOMY FOR PROSTATE CANCER: WHAT REALLY MATTERS?
(Blackwell Publishing Ltd, 2007-09)