Now showing items 11-20 of 24
Bayesian inference for the stereotype regression model: Application to a case–control study of prostate cancer
(John Wiley & Sons, Ltd., 2009-11-10)
The stereotype regression model for categorical outcomes, proposed by Anderson ( J. Roy. Statist. Soc. B. 1984; 46 :1–30) is nested between the baseline-category logits and adjacent category logits model with proportional ...
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
PAR1-mediated NFΚB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
We have previously reported that protease-activated receptor 1 (PAR1 or thrombin receptor) is over-expressed in metastatic prostate cancer cell lines compared to prostate epithelial cells. In this study, we examined 1,074 ...
Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05-01)
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein-1 (MCP-1, CCL2) has been identified ...
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-01)
Patients with advanced prostate cancer often exhibit increased activation of the coagulation system. The key activator of the coagulation cascade is the serine protease thrombin which is capable of eliciting numerous ...
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
(Springer-Verlag, 2006-02)
Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility ...
A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
The pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous “hurdle” to overcome in designing novel cancer ...
Evidence for lectin signaling to the nuclear matrix: Cellular interpretation of the glycocode
(John Wiley & Sons, Inc., 2000)
No abstract
Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2008-10-01)
One of the most life-threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. Our work in this field has ...
Phase II trial of fenretinide in advanced renal carcinoma
(Kluwer Academic Publishers; Springer Science + Business Media, Inc., 2005-01)
Purpose : Fenretinide, a synthetic form of retinoid, induced apoptosis even in chemotherapy resistant cell lines. A phase II study was hence conducted to evaluate toxicity and efficacy of fenretinide in metastatic renal ...