Now showing items 11-20 of 23
Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05-01)
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein-1 (MCP-1, CCL2) has been identified ...
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-01)
Patients with advanced prostate cancer often exhibit increased activation of the coagulation system. The key activator of the coagulation cascade is the serine protease thrombin which is capable of eliciting numerous ...
CXCL12 overexpression and secretion by aging fibroblasts enhance human prostate epithelial proliferation in vitro
(Blackwell Science Ltd, 2005-12)
The direct relationship between the aging process and the incidence and prevalence of both benign prostatic hyperplasia (BPH) and prostate cancer (PCa) implies that certain risk factors associated with the development of ...
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
(Springer-Verlag, 2006-02)
Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility ...
A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
The pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous “hurdle” to overcome in designing novel cancer ...
Evidence for lectin signaling to the nuclear matrix: Cellular interpretation of the glycocode
(John Wiley & Sons, Inc., 2000)
No abstract
Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
(Wiley Subscription Services, Inc., A Wiley Company, 2008-10-01)
One of the most life-threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. Our work in this field has ...
Alterations in antigen expression in superficial bladder cancer Supported by grant PDT-409 from the American Cancer Society and grant CA56973 from the National Cancer Institute.
(Wiley Subscription Services, Inc., A Wiley Company, 1992)
Bladder cancer can be viewed as a prototype for carcinogen-induced neoplasia. This has been demonstrated experimentally in a variety of systems and in man through epidemiological studies of occupational exposure to putative ...
The biology of a prostate cancer metastasis suppressor protein: Raf kinase inhibitor protein
(Wiley Subscription Services, Inc., A Wiley Company, 2005-02-01)
Raf kinase inhibitor protein (RKIP) was originally identified as a protein that bound membrane phospholipids and was named phosphatidylethanolamine binding protein-2 (PEBP-2). RKIP was than identified as a protein that ...
CCR2 expression correlates with prostate cancer progression
(Wiley Subscription Services, Inc., A Wiley Company, 2007-06-01)
Although the primary role of chemokines and their receptors is controlling the trafficking of leukocytes during inflammatory responses, they also play pleoitropic roles in cancer development. There is emerging evidence ...