Now showing items 11-20 of 28
The role of the disintegrin metalloproteinase ADAM15 in prostate cancer progression
(Wiley Subscription Services, Inc., A Wiley Company, 2009-04-15)
The metalloproteinase ADAM15 is a multi-domain disintegrin protease that is upregulated in a variety of human cancers. ADAM15 mRNA and protein levels are increased in prostate cancer and its expression is significantly ...
Bayesian inference for the stereotype regression model: Application to a case–control study of prostate cancer
(John Wiley & Sons, Ltd., 2009-11-10)
The stereotype regression model for categorical outcomes, proposed by Anderson ( J. Roy. Statist. Soc. B. 1984; 46 :1–30) is nested between the baseline-category logits and adjacent category logits model with proportional ...
Phase II study of oral bis (aceto) ammine dichloro (cyclohexamine) platinum (IV) (JM-216, BMS-182751) given daily x 5 in hormone refractory prostate cancer (HRPC)
(Kluwer Academic Publishers; Springer Science+Business Media, 2005-01)
JM-216 is an orally bioavailable platinum compound with activity against many tumor models. The objective of this study was to determine the safety profile and anti-tumor activity of JM-216 in patients with hormone refractory ...
PAR1-mediated NFΚB activation promotes survival of prostate cancer cells through a Bcl-xL-dependent mechanism
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
We have previously reported that protease-activated receptor 1 (PAR1 or thrombin receptor) is over-expressed in metastatic prostate cancer cell lines compared to prostate epithelial cells. In this study, we examined 1,074 ...
Synergy between anti-CCL2 and docetaxel as determined by DW-MRI in a metastatic bone cancer model
(Wiley Subscription Services, Inc., A Wiley Company, 2009-05-01)
Metastatic prostate cancer continues to be the second leading cause of cancer death in American men with an estimated 28,660 deaths in 2008. Recently, monocyte chemoattractant protein-1 (MCP-1, CCL2) has been identified ...
PAR1-mediated RhoA activation facilitates CCL2-induced chemotaxis in PC-3 cells
(Wiley Subscription Services, Inc., A Wiley Company, 2007-08-01)
Patients with advanced prostate cancer often exhibit increased activation of the coagulation system. The key activator of the coagulation cascade is the serine protease thrombin which is capable of eliciting numerous ...
Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression
(Nature Publishing Group, 2008-02-11)
Multiple, complex molecular events characterize cancer development and progression(1,2). Deciphering the molecular networks that distinguish organ- confined disease from metastatic disease may lead to the identification ...
Two-locus genome-wide linkage scan for prostate cancer susceptibility genes with an interaction effect
(Springer-Verlag, 2006-02)
Prostate cancer represents a significant worldwide public health burden. Epidemiological and genetic epidemiological studies have consistently provided data supporting the existence of inherited prostate cancer susceptibility ...
The Cenozoic palaeoenvironment of the Arctic Ocean
(Nature Publishing Group, 2006-06-01)
The history of the Arctic Ocean during the Cenozoic era ( 0 - 65 million years ago) is largely unknown from direct evidence. Here we present a Cenozoic palaeoceanographic record constructed from >400 m of sediment core ...
A paradigm for the treatment of prostate cancer bone metastases based on an understanding of tumor cell–microenvironment interactions
(Wiley Subscription Services, Inc., A Wiley Company, 2005-10-15)
The pliability of cancer cells to mutate into several different phenotypes in an attempt to find one that will survive and colonize at the metastatic site is a tremendous “hurdle” to overcome in designing novel cancer ...