Now showing items 1-10 of 38
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
(Nature Publishing Group, 2007-08-02)
Recently, we identified recurrent gene fusions involving the 59 untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers(1,2). ...
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
(Springer-Verlag, 2006-05)
Epidemiological and twin studies have consistently demonstrated a strong genetic component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have been performed to identify chromosomal regions ...
The intraperitoneal delivery of radiolabeled monoclonal antibodies: studies on the regional delivery advantage
(Springer-Verlag, 1988-06)
The i.p. delivery of murine monoclonal antibody was compared with i.v. delivery in normal mice and rats, in normal nude mice and in those with i.p. human ovarian carcinoma xenografts. In normal rats, all classes of antibodies ...
Effect of organ site on nuclear matrix protein composition
(Wiley Subscription Services, Inc., A Wiley Company, 1996-07)
The nuclear matrix has been linked to several important cellular functions within cells, such as DNA organization and replication, as well as regulation of gene expression. It has been reported that the nuclear matrix ...
Chemotherapy for prostate cancer: implementing early systemic therapy to improve outcomes
(Springer-Verlag, 2005-11)
Prostate cancer remains a significant health concern for men in the USA as it is a leading cancer diagnosis and a cause of death. With the use of prostate-specific antigen or screening, a stage migration has occurred with ...
Semiparametric Bayesian modeling of random genetic effects in family-based association studies
(John Wiley & Sons, Ltd., 2009-01-15)
We consider the inference problem of estimating covariate and genetic effects in a family-based case-control study where families are ascertained on the basis of the number of cases within the family. However, our interest ...
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
(Wiley Subscription Services, Inc., A Wiley Company, 2003-06-01)
Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead ...
New trends in the treatment of bone metastasis
(Wiley Subscription Services, Inc., A Wiley Company, 2007-12-01)
Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective ...
A semi-automated fluorescent (SAF) assay using viable, whole cells for screening hybridoma supernatants
(Elsevier, 1987-06-16)
In the production of monoclonal antibodies, a rapid, sensitive, accurate assay is needed for the critical step of screening. We report the modification of an assay using viable whole cells for screening hybridoma supernatants. ...
Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-Α
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-15)
An unbiased cDNA expression phage library derived from bone-marrow endothelial cells was used to identify novel surface adhesion molecules that might participate in metastasis. Herein we report that reticulocalbin 1 (RCN1) ...