Now showing items 1-10 of 28
Distinct classes of chromosomal rearrangements create oncogenic ETS gene fusions in prostate cancer
(Nature Publishing Group, 2007-08-02)
Recently, we identified recurrent gene fusions involving the 59 untranslated region of the androgen-regulated gene TMPRSS2 and the ETS (E26 transformation-specific) family genes ERG, ETV1 or ETV4 in most prostate cancers(1,2). ...
Genome-wide linkage scan for prostate cancer susceptibility genes in men with aggressive disease: significant evidence for linkage at chromosome 15q12
(Springer-Verlag, 2006-05)
Epidemiological and twin studies have consistently demonstrated a strong genetic component to prostate cancer (PCa) susceptibility. To date, numerous linkage studies have been performed to identify chromosomal regions ...
Chemotherapy for prostate cancer: implementing early systemic therapy to improve outcomes
(Springer-Verlag, 2005-11)
Prostate cancer remains a significant health concern for men in the USA as it is a leading cancer diagnosis and a cause of death. With the use of prostate-specific antigen or screening, a stage migration has occurred with ...
Semiparametric Bayesian modeling of random genetic effects in family-based association studies
(John Wiley & Sons, Ltd., 2009-01-15)
We consider the inference problem of estimating covariate and genetic effects in a family-based case-control study where families are ascertained on the basis of the number of cases within the family. However, our interest ...
Expression of CXCR4 and CXCL12 (SDF-1) in human prostate cancers (PCa) in vivo
(Wiley Subscription Services, Inc., A Wiley Company, 2003-06-01)
Human prostate cancers (PCa) express great variability in their ability to metastasize to bone. The identification of molecules associated with aggressive phenotypes will help to define PCa subsets and will ultimately lead ...
New trends in the treatment of bone metastasis
(Wiley Subscription Services, Inc., A Wiley Company, 2007-12-01)
Bone metastasis is often the penultimate harbinger of death for many cancer patients. Bone metastases are often associated with fractures and severe pain resulting in decreased quality of life. Accordingly, effective ...
Novel surface expression of reticulocalbin 1 on bone endothelial cells and human prostate cancer cells is regulated by TNF-Α
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-15)
An unbiased cDNA expression phage library derived from bone-marrow endothelial cells was used to identify novel surface adhesion molecules that might participate in metastasis. Herein we report that reticulocalbin 1 (RCN1) ...
Prostate cancer bone metastases promote both osteolytic and osteoblastic activity
(Wiley Subscription Services, Inc., A Wiley Company, 2004-03-01)
Advanced prostate cancer is frequently accompanied by the development of metastasis to bone. In the past, prostate cancer bone metastases were characterized as being osteoblastic (i.e., increasing bone density) based on ...
CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac
(Wiley Subscription Services, Inc., A Wiley Company, 2008-08-01)
Nearly 85% of the men who will die of prostate cancer (PCa) have skeletal metastases present. The ability of PCa cells to interact with the microenvironment determines the success of the tumor cell to form metastatic ...
Prostate cancer promotes CD11b positive cells to differentiate into osteoclasts
(Wiley Subscription Services, Inc., A Wiley Company, 2009-03-01)
Bone is the preferred site of prostate cancer metastasis, contributing to the morbidity and mortality of this disease. A key step in the successful establishment of prostate cancer bone metastases is activation of osteoclasts ...