CD163 expression in leukemia cutis
dc.contributor.author | Harms, Paul W. | en_US |
dc.contributor.author | Bandarchi, Bizhan | en_US |
dc.contributor.author | Ma, Linglei | en_US |
dc.date.accessioned | 2011-01-13T19:38:27Z | |
dc.date.available | 2011-01-13T19:38:27Z | |
dc.date.issued | 2010-09 | en_US |
dc.identifier.citation | Harms, Paul W.; Bandarchi, Bizhan; Ma, Linglei; (2010). "CD163 expression in leukemia cutis." Journal of Cutaneous Pathology 37(9): 953-957. <http://hdl.handle.net/2027.42/78608> | en_US |
dc.identifier.issn | 0303-6987 | en_US |
dc.identifier.issn | 1600-0560 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78608 | |
dc.description.abstract | Background: Proper diagnosis of myeloid leukemia cutis (LC) is of great clinical importance but can be difficult because no single immunohistochemical marker is adequately sensitive or specific for definitive diagnosis. Thus, a broader panel of markers is often desirable. CD163 is highly specific for normal and neoplastic cells of the monocyte/histiocyte lineage. In this study, we examined the value of CD163 in the diagnosis of acute myeloid LC. Methods: A total of 34 cases, including 18 cases of myelomonocytic or monocytic LC, 10 cases of myeloid LC without monocytic component and 6 cases of acute lymphoblastic leukemia/lymphoma (ALL), were stained with CD163. Results: CD163 was expressed in 8 of 18 (44%) of myelomonocytic or monocytic LC and 1 of 10 (10%) of other myeloid LC, but in none of the ALL cases (0/6). CD163 was highly specific (90%) for myeloid LC with a monocytic component, but showed low sensitivity in the diagnosis of both myeloid LC in general (24%) and myeloid LC with a monocytic component (44%). Conclusions: Our results suggest that CD163 has utility as a specific marker for myeloid LC in conjunction with currently used immunohistochemical stains, but should not be used alone for diagnosis.Harms PW, Bandarchi B, Ma L. CD163 expression in leukemia cutis. | en_US |
dc.format.extent | 803620 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.title | CD163 expression in leukemia cutis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dermatology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Dermatology, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Applied Molecular Oncology, University of Toronto, Princess Margaret Hospital and Ontario Cancer Institute, Toronto, Canada | en_US |
dc.identifier.pmid | 20175823 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78608/1/j.1600-0560.2010.01533.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-0560.2010.01533.x | en_US |
dc.identifier.source | Journal of Cutaneous Pathology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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