Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule
dc.contributor.author | Kloetzer, L. | en_US |
dc.contributor.author | Chey, William D. | en_US |
dc.contributor.author | Mccallum, R. W. | en_US |
dc.contributor.author | Koch, K. L. | en_US |
dc.contributor.author | Wo, J. M. | en_US |
dc.contributor.author | Sitrin, M. D. | en_US |
dc.contributor.author | Katz, L. A. | en_US |
dc.contributor.author | Lackner, J. M. | en_US |
dc.contributor.author | Parkman, Henry P. | en_US |
dc.contributor.author | Wilding, G. E. | en_US |
dc.contributor.author | Semler, J. R. | en_US |
dc.contributor.author | Hasler, William L. | en_US |
dc.contributor.author | Kuo, B. | en_US |
dc.date.accessioned | 2011-01-13T19:39:38Z | |
dc.date.available | 2011-01-13T19:39:38Z | |
dc.date.issued | 2010-05 | en_US |
dc.identifier.citation | Kloetzer, L. ; Chey, W. D. ; Mccallum, R. W. ; Koch, K. L. ; Wo, J. M. ; Sitrin, M. ; Katz, L. A. ; Lackner, J. M. ; Parkman, H. P. ; Wilding, G. E. ; Semler, J. R. ; Hasler, W. L. ; Kuo, B. ; (2010). "Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule." Neurogastroenterology & Motility 22(5): 527-e117. <http://hdl.handle.net/2027.42/78624> | en_US |
dc.identifier.issn | 1350-1925 | en_US |
dc.identifier.issn | 1365-2982 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78624 | |
dc.description.abstract | The wireless motility capsule (WMC) measures intraluminal pH and pressure, and records transit time and contractile activity throughout the gastrointestinal tract. Our hypothesis is that WMC can differentiate antroduodenal pressure profiles between healthy people and patients with upper gut motility dysfunctions.This study aims to analyze differences in the phasic pressure profiles of the stomach and small intestine in healthy and gastroparetic subjects.Data from 71 healthy and 42 gastroparetic subjects were analyzed. The number of contractions (Ct), area under the pressure curve and motility index (MI = Ln (Ct *sum amplitudes +1)) were analyzed for 60 min before gastric emptying of the capsule (GET), (gastric window) and after GET (small bowel window) and results between groups were compared with the Wilcoxon rank sum test.Significant differences were observed between healthy and gastroparetic subjects for Ct and MI ( P < 0.05). Median values of the motility parameters in gastric window were Ct = 72, MI = 11.83 for healthy and Ct = 47, MI = 11.12 for gastroparetics. In the small bowel, median values were Ct = 144.5, MI = 12.78 for healthy and Ct = 93, MI = 12.12 for gastroparetics. Diabetic subjects with gastroparesis showed significantly lower Ct and MI compared with healthy subjects in both gastric and small bowel windows while idiopathic gastroparetic subjects did not show significant differences.The WMC is able to differentiate between healthy and gastroparetic subjects based on gastric and small bowel motility profiles. | en_US |
dc.format.extent | 709453 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Ambulatory Capsule | en_US |
dc.subject.other | Gastroparesis | en_US |
dc.subject.other | Manometry | en_US |
dc.title | Motility of the antroduodenum in healthy and gastroparetics characterized by wireless motility capsule | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Gastroenterology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA | en_US |
dc.contributor.affiliationother | Center for Gastrointestinal Nerve & Muscle Function & GI Motility, University of Kansas Medical Center, Kansas City, KS, USA | en_US |
dc.contributor.affiliationother | Gastroenterology, Wake Forest University Baptist Medical Center, Winston Salem, NC, USA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology/Hepatology, University of Louisville, Louisville, KY, USA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, Western New York VA Medical Center, SUNY at Buffalo, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University at Buffalo School of Medicine, SUNY, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, Behavioral Medicine Clinic, University at Buffalo School of Medicine, SUNY, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | Gastroenterology Section, Department of Medicine, Temple University School of Medicine, Philadelphia, PA, USA | en_US |
dc.contributor.affiliationother | Department of Biostatistics, SUNY at Buffalo, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | The Smart Pill Corporation, Buffalo, NY, USA | en_US |
dc.identifier.pmid | 20122128 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78624/1/j.1365-2982.2010.01468.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2982.2010.01468.x | en_US |
dc.identifier.source | Neurogastroenterology & Motility | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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