Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High-Fat Diet
dc.contributor.author | Rocchini, Albert P. | en_US |
dc.contributor.author | Yang, John Q. | en_US |
dc.contributor.author | Smith, Marla J. | en_US |
dc.contributor.author | Supiano, Mark A. | en_US |
dc.date.accessioned | 2011-01-13T19:40:14Z | |
dc.date.available | 2011-01-13T19:40:14Z | |
dc.date.issued | 2010-02 | en_US |
dc.identifier.citation | Rocchini, Albert P.; Yang, John Q.; Smith, Marla J.; Supiano, Mark A.; (2010). "Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High-Fat Diet." The Journal of Clinical Hypertension 12(2): 117-124. <http://hdl.handle.net/2027.42/78633> | en_US |
dc.identifier.issn | 1524-6175 | en_US |
dc.identifier.issn | 1751-7176 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78633 | |
dc.description.abstract | J Clin Hypertens (Greenwich). 2010;12:117–124. © 2009 Wiley Periodicals, Inc. The role of increased sympathetic nervous system (SNS) activity in the pathogenesis of obesity hypertension and insulin resistance is controversial. Eight dogs were instrumented and fed a high-fat diet (HFD) for 6 weeks. Dogs were evaluated for changes in weight, blood pressure, insulin resistance, and norepinephrine (NE) kinetics using a two-compartment model. The HFD resulted in weight gain, hypertension, and insulin resistance. During the 6 weeks of the HFD, although plasma NE concentration trended toward increasing ( P =.09), SNS, assessed by NE kinetic studies, significantly increased ( P =.009). Within 1 week of starting the HFD, NE release into the extravascular compartment (NE 2 ) increased from 3.44±0.59 μg/mL to 4.87±0.80 μg/mL ( P <.01) and this increase was maintained over the next 5 weeks of the HFD (NE 2 at week 6 was 4.66±0.97 μg/mL). In addition to the increased NE 2 there was also a significant increase in NE clearance ( P =.04). There were significant correlations between the increase in NE 2 and both the development of insulin resistance and hypertension. This study supports the hypothesis that activation of the SNS plays a pivotal role in the metabolic and hemodynamic changes that occur with weight gain induced by HFD. | en_US |
dc.format.extent | 244923 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.title | Serial Changes in Norepinephrine Kinetics Associated With Feeding Dogs a High-Fat Diet | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI; and the | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, Geriatrics Division, and Center on Aging, University of Utah, Salt Lake City, UT; 3 | en_US |
dc.identifier.pmid | 20167039 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78633/1/j.1751-7176.2009.00230.x.pdf | |
dc.identifier.doi | 10.1111/j.1751-7176.2009.00230.x | en_US |
dc.identifier.source | The Journal of Clinical Hypertension | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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