The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B
dc.contributor.author | Lapinski, Philip E. | en_US |
dc.contributor.author | Oliver, Jennifer A. | en_US |
dc.contributor.author | Bodie, Jennifer N. | en_US |
dc.contributor.author | Marti, Francesc | en_US |
dc.contributor.author | King, Philip D. | en_US |
dc.date.accessioned | 2011-01-13T19:41:19Z | |
dc.date.available | 2011-01-13T19:41:19Z | |
dc.date.issued | 2009-11 | en_US |
dc.identifier.citation | Lapinski, Philip E.; Oliver, Jennifer A.; Bodie, Jennifer N.; Marti, Francesc; King, Philip D.; (2009). "The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B." Immunological Reviews 232(1 Organization of Immunoreceptor Signaling by Adapters ): 240-254. <http://hdl.handle.net/2027.42/78649> | en_US |
dc.identifier.issn | 0105-2896 | en_US |
dc.identifier.issn | 1600-065X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78649 | |
dc.description.abstract | Adapter proteins play key roles in intracellular signal transduction through complex formation with catalytically active signaling molecules. In T lymphocytes, the role of several different types of adapter proteins in T-cell antigen receptor signal transduction is well established. An exception to this is the family of T-cell-specific adapter (TSAd) proteins comprising of TSAd, adapter protein of unknown function (ALX), SH2D4A, and SH2D4B. Only recently has the function of these adapters in T-cell signal transduction been explored. Here, we discuss advances in our understanding of the role of this family of adapter proteins in T cells. Their function as regulators of signal transduction in other cell types is also discussed. | en_US |
dc.format.extent | 170297 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Adapter Proteins | en_US |
dc.subject.other | Protein Tyrosine Kinases | en_US |
dc.subject.other | Signal Transduction | en_US |
dc.subject.other | T Lymphocytes | en_US |
dc.subject.other | Autoimmunity | en_US |
dc.subject.other | Knockout Mice | en_US |
dc.title | The T-cell-specific adapter protein family: TSAd, ALX, and SH2D4A/SH2D4B | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI, USA. | en_US |
dc.identifier.pmid | 19909368 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78649/1/j.1600-065X.2009.00829.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-065X.2009.00829.x | en_US |
dc.identifier.source | Immunological Reviews | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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