Fungemia Associated with Left Ventricular Assist Device Support
dc.contributor.author | Bagdasarian, Natasha G. | en_US |
dc.contributor.author | Malani, Anurag N. | en_US |
dc.contributor.author | Pagani, Francis D. | en_US |
dc.contributor.author | Malani, Preeti N. | en_US |
dc.date.accessioned | 2011-01-13T19:52:56Z | |
dc.date.available | 2011-01-13T19:52:56Z | |
dc.date.issued | 2009-11 | en_US |
dc.identifier.citation | Bagdasarian, Natasha G.; Malani, Anurag N.; Pagani, Francis D.; Malani, Preeti N.; (2009). "Fungemia Associated with Left Ventricular Assist Device Support." Journal of Cardiac Surgery 24(6): 763-765. <http://hdl.handle.net/2027.42/78694> | en_US |
dc.identifier.issn | 0886-0440 | en_US |
dc.identifier.issn | 1540-8191 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78694 | |
dc.description.abstract | Objective: Infections remain an important complication of left ventricular assist device (LVAD) support. While relatively uncommon, fungal infections present a serious concern given a high association with adverse events including death. We sought to further characterize the epidemiology of fungemias during LVAD support. Methods: Retrospective review of 292 patients receiving LVAD support from October 1996 to April 2009 at the University of Michigan Health System was done. Results: Seven cases of LVAD-associated fungemia were observed during the study period (0.1 infections/1000 days of device support). Five patients had infection with Candida species and two with Aspergillus species. The two patients with Aspergillus infection presented with disseminated disease, quickly dying of multiorgan failure, and sepsis. All five patients with Candida infections were successfully treated with systemic antifungal therapy along with transplantation in four of five patients. The fifth patient is receiving mechanical support as destination therapy. He remains on long-term suppression with high-dose fluconazole. Conclusions: Fungal infections appear to be a rare but serious complication of LVAD support. Future studies should aim to improve our understanding of risk factors for fungal infection during mechanical support, especially disseminated Aspergillus . Short-term perioperative antifungal prophylaxis with fluconazole appears to be an effective and reasonable approach to prevention. (J Card Surg 2009;24:763–765) | en_US |
dc.format.extent | 54105 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.title | Fungemia Associated with Left Ventricular Assist Device Support | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Infectious Diseases, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, Section of Cardiothoracic Surgery, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Geriatric Medicine, University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Geriatric Research Education and Clinical Center (GRECC), University of Michigan Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Saint Joseph Mercy Health System, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | VA Ann Arbor Healthcare System, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 20078725 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78694/1/j.1540-8191.2009.00919.x.pdf | |
dc.identifier.doi | 10.1111/j.1540-8191.2009.00919.x | en_US |
dc.identifier.source | Journal of Cardiac Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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