A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots
dc.contributor.author | Lu, Xincheng | en_US |
dc.contributor.author | Rios, Hector F. | en_US |
dc.contributor.author | Jiang, Baichun | en_US |
dc.contributor.author | Xing, Lianping | en_US |
dc.contributor.author | Kadlcek, Renata | en_US |
dc.contributor.author | Greenfield, Edward M. | en_US |
dc.contributor.author | Luo, Guangbin | en_US |
dc.contributor.author | Feng, Jian Q. | en_US |
dc.date.accessioned | 2011-01-13T19:54:58Z | |
dc.date.available | 2011-01-13T19:54:58Z | |
dc.date.issued | 2009-12 | en_US |
dc.identifier.citation | Lu, Xincheng; Rios, Hector F.; Jiang, Baichun; Xing, Lianping; Kadlcek, Renata; Greenfield, Edward M.; Luo, Guangbin; Feng, Jian Q.; (2009). "A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots." European Journal of Oral Sciences 117(6): 625-635. <http://hdl.handle.net/2027.42/78724> | en_US |
dc.identifier.issn | 0909-8836 | en_US |
dc.identifier.issn | 1600-0722 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/78724 | |
dc.description.abstract | A new spontaneous mouse mutant ( ntl ) with autosomal-recessive osteopetrosis was characterized. These mice formed tartrate-resistant acid phosphate (TRAP)-positive osteoclasts but their osteoclasts had no ruffled border and did not resorb bone. These mice displayed no tooth eruption or tooth root formation. Adult mutant mice developed odontoma-like proliferations near the proximal ends of the incisors. Intraperitoneal injection of progenitor cells from the liver of 16.5 days postcoitum wild-type embryos into newborn mutants rescued the osteopetrosis phenotype, indicating that the defects were intrinsic to the osteoclasts. Our findings not only provide further support for a critical role of osteoclasts in tooth eruption and tooth root development, but also suggest that the perturbation of the homeostasis of the odontogenic precursors of the incisors is primarily responsible for the development of the odontoma-like proliferations in this osteopetrosis mutant. Genetic mapping has narrowed down the location of the mutant allele to a genetic interval of 3.2 cM on mouse chromosome 17. | en_US |
dc.format.extent | 904266 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Odontoma-like Proliferations | en_US |
dc.subject.other | Osteoclast | en_US |
dc.subject.other | Osteopetrosis | en_US |
dc.subject.other | Tooth Eruption | en_US |
dc.subject.other | Tooth Root Formation | en_US |
dc.title | A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Dentistry | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan School of Dentistry 1011 N. University Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Department of Genetics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA | en_US |
dc.contributor.affiliationother | Case Comprehensive Cancer Center, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA | en_US |
dc.contributor.affiliationother | Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX, USA | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA | en_US |
dc.contributor.affiliationother | Department of Orthopaedics, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH, USA | en_US |
dc.identifier.pmid | 20121924 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/78724/1/EOS_690_sm_FigS1.pdf | |
dc.identifier.doi | 10.1111/j.1600-0722.2009.00690.x | en_US |
dc.identifier.source | European Journal of Oral Sciences | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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