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Hyperlipidemia: a new therapeutic target for diabetic neuropathy

dc.contributor.authorVincent, Andrea M.en_US
dc.contributor.authorHinder, Lucy M.en_US
dc.contributor.authorPop-Busui, Rodicaen_US
dc.contributor.authorFeldman, Eva L.en_US
dc.date.accessioned2011-01-13T19:55:14Z
dc.date.available2011-01-13T19:55:14Z
dc.date.issued2009-12en_US
dc.identifier.citationVincent, Andrea M.; Hinder, Lucy M.; Pop-Busui, Rodica; Feldman, Eva L.; (2009). "Hyperlipidemia: a new therapeutic target for diabetic neuropathy." Journal of the Peripheral Nervous System 14(4): 257-267. <http://hdl.handle.net/2027.42/78728>en_US
dc.identifier.issn1085-9489en_US
dc.identifier.issn1529-8027en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/78728
dc.description.abstractAbstract Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.en_US
dc.format.extent714075 bytes
dc.format.extent3106 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.subject.otherLow-density Lipoproteinen_US
dc.subject.otherMitochondriaen_US
dc.subject.otherNAD(P)H Oxidaseen_US
dc.subject.otherOxLDLen_US
dc.subject.otherTriglyceridesen_US
dc.titleHyperlipidemia: a new therapeutic target for diabetic neuropathyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelNeurosciencesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Neurologyen_US
dc.identifier.pmid20021567en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/78728/1/j.1529-8027.2009.00237.x.pdf
dc.identifier.doi10.1111/j.1529-8027.2009.00237.xen_US
dc.identifier.sourceJournal of the Peripheral Nervous Systemen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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