Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation
dc.contributor.author | Camilleri, Michael | en_US |
dc.contributor.author | Thorne, N. K. | en_US |
dc.contributor.author | Ringel, Y. | en_US |
dc.contributor.author | Hasler, William L. | en_US |
dc.contributor.author | Kuo, B. | en_US |
dc.contributor.author | Esfandyari, T. | en_US |
dc.contributor.author | Gupta, A. | en_US |
dc.contributor.author | Scott, S. M. | en_US |
dc.contributor.author | Mccallum, R. W. | en_US |
dc.contributor.author | Parkman, Henry P. | en_US |
dc.contributor.author | Soffer, E. E. | en_US |
dc.contributor.author | Wilding, G. E. | en_US |
dc.contributor.author | Semler, J. R. | en_US |
dc.contributor.author | Rao, S. S. C. | en_US |
dc.date.accessioned | 2011-01-31T17:22:52Z | |
dc.date.available | 2011-10-03T17:19:14Z | en_US |
dc.date.issued | 2010-08 | en_US |
dc.identifier.citation | Camilleri, M. ; Thorne, N. K. ; Ringel, Y. ; Hasler, W. L. ; Kuo, B. ; Esfandyari, T. ; Gupta, A. ; Scott, S. M. ; Mccallum, R. W. ; Parkman, H. P. ; Soffer, E. ; Wilding, G. E. ; Semler, J. R. ; Rao, S. S.C. ; (2010). "Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation." Neurogastroenterology & Motility 22(8): 874-e233. <http://hdl.handle.net/2027.42/79053> | en_US |
dc.identifier.issn | 1350-1925 | en_US |
dc.identifier.issn | 1365-2982 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79053 | |
dc.description.abstract | Colon transit (CT) measurements are used in the management of significant constipation. The radiopaque marker (ROM) method provides limited information.We proposed to validate wireless motility capsule (WMC), that measures pH, pressure and temperature, to ROM measurement of CT in patients with symptomatic constipation evaluated at multiple centers. Of 208 patients recruited, 158 eligible patients underwent simultaneous measurement of colonic transit time (CTT) using ROM (Metcalf method, cut off for delay >67 h), and WMC (cutoff for delay >59 h). The study was designed to demonstrate substantial equivalence, defined as diagnostic agreement >65% for patients who had normal or delayed ROM transit.Fifty-nine of 157 patients had delayed ROM CT. Transit results by the two methods differed: ROM median 55.0 h [IQR 31.0–85.0] and WMC (43.5 h [21.7–70.3], P < 0.001. The positive percent agreement between WMC and ROM for delayed transit was ∼80%; positive agreement in 47 by WMC/59 by ROM or 0.796 (95% CI = 0.67–0.98); agreement vs null hypothesis (65%) P = 0.01. The negative percent agreement (normal transit) was ∼91%: 89 by WMC/98 by ROM or 0.908 (95% CI = 0.83–0.96); agreement vs null hypothesis (65%), P = 0.00001. Overall device agreement was 87%. There were significant correlations ( P < 0.001) between ROM and WMC transit (CTT [ r = 0.707] and between ROM and combined small and large bowel transit [ r = 0.704]). There were no significant adverse events.The 87% overall agreement (positive and negative) validates WMC relative to ROM in differentiating slow vs normal CT in a multicenter clinical study of constipation. | en_US |
dc.format.extent | 732793 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Colonic Transit Time | en_US |
dc.subject.other | Correlation | en_US |
dc.subject.other | Negative Agreement | en_US |
dc.subject.other | Positive Agreement | en_US |
dc.subject.other | Radiopaque Markers | en_US |
dc.subject.other | Wireless Motility Capsule | en_US |
dc.title | Wireless pH-motility capsule for colonic transit: prospective comparison with radiopaque markers in chronic constipation | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Medicine, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | College of Medicine, Mayo Clinic, Rochester, MN, USA | en_US |
dc.contributor.affiliationother | Wake Forest University Medical Center, Winston Salem, NC, USA | en_US |
dc.contributor.affiliationother | University of North Carolina Medical Center, Chapel Hill, NC, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Massachusetts General Hospital, Boston, MA, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Kansas University Medical Center, Kansas City, KS, USA | en_US |
dc.contributor.affiliationother | University of Buffalo VA Medical Center, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | Queen Mary University, London, UK | en_US |
dc.contributor.affiliationother | Texas Tech University, El Paso, TX, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, Temple University, Philadelphia, PA, USA | en_US |
dc.contributor.affiliationother | Cedars-Sinai Medical Center, Los Angeles, CA, USA | en_US |
dc.contributor.affiliationother | Department of Biostatistics, State University of New York at Buffalo, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | SmartPill Corporation, Buffalo, NY, USA | en_US |
dc.contributor.affiliationother | Department of Medicine, University of Iowa, Iowa City, IA, USA | en_US |
dc.identifier.pmid | 20465593 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79053/1/j.1365-2982.2010.01517.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2982.2010.01517.x | en_US |
dc.identifier.source | Neurogastroenterology & Motility | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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