Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma
dc.contributor.author | Dorsam, Glenn P. | en_US |
dc.contributor.author | Hoselton, Scott A. | en_US |
dc.contributor.author | Sandy, Ashley R. | en_US |
dc.contributor.author | Samarasinghe, Amali E. | en_US |
dc.contributor.author | Vomhof-Dekrey, Emilie E. | en_US |
dc.contributor.author | Dorsam, Sheri T. | en_US |
dc.contributor.author | Schuh, Jane M. | en_US |
dc.date.accessioned | 2011-01-31T17:26:28Z | |
dc.date.available | 2011-11-01T15:13:01Z | en_US |
dc.date.issued | 2010-09 | en_US |
dc.identifier.citation | Dorsam, Glenn P.; Hoselton, Scott A.; Sandy, Ashley R.; Samarasinghe, Amali E.; Vomhof-Dekrey, Emilie E.; Dorsam, Sheri T.; Schuh, Jane M.; (2010). "Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma." Microbiology and Immunology 54(9): 558-563. <http://hdl.handle.net/2027.42/79085> | en_US |
dc.identifier.issn | 0385-5600 | en_US |
dc.identifier.issn | 1348-0421 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79085 | |
dc.description.abstract | The Aspergillus fumigatus mouse model of asthma mimics the characteristics of human fungal asthma, including local and systemic inflammation. Monocyte/macrophage lineage cells direct innate immune responses and guide adaptive responses. To identify gene expression changes in peripheral blood monocytes in the context of fungal allergy, mice were exposed to systemic and intranasal inoculations of fungal antigen (sensitized), and naïve and sensitized animals were challenged intratracheally with live A. fumigatus conidia. Microarray analysis of blood monocytes from allergic versus non-allergic mice showed ≥ twofold modulation of 45 genes. Ingenuity pathway analysis revealed a network of these genes involved in antigen presentation, inflammation, and immune cell trafficking. These data show that allergen sensitization and challenge affects gene expression in peripheral monocytes. | en_US |
dc.format.extent | 239520 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Asia | en_US |
dc.subject.other | Allergy | en_US |
dc.subject.other | Aspergillus Fumigatus | en_US |
dc.subject.other | Microarray | en_US |
dc.subject.other | Monocytes | en_US |
dc.title | Gene expression profiling and network analysis of peripheral blood monocytes in a chronic model of allergic asthma | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Center for Stem Cell Biology, Life Sciences Institute, University of Michigan, Room 6382A, 210 Washtenaw Ave, Ann Arbor, MI 48109, USA | en_US |
dc.contributor.affiliationother | Department of Chemistry and Molecular Biology, North Dakota State University, Dept 2710, PO Box 6050 | en_US |
dc.contributor.affiliationother | Center for Protease Research, North Dakota State University, Dept 2735, PO Box 6050 | en_US |
dc.contributor.affiliationother | Department of Veterinary and Microbiological Sciences, North Dakota State University, Van Es Hall, Room 187, Fargo, North Dakota, 58108 | en_US |
dc.identifier.pmid | 20840155 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79085/1/j.1348-0421.2010.00242.x.pdf | |
dc.identifier.doi | 10.1111/j.1348-0421.2010.00242.x | en_US |
dc.identifier.source | Microbiology and Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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