Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States
dc.contributor.author | Burton, F. | en_US |
dc.contributor.author | Alkaade, S. | en_US |
dc.contributor.author | Collins, D. | en_US |
dc.contributor.author | Muddana, V. | en_US |
dc.contributor.author | Slivka, A. | en_US |
dc.contributor.author | Brand, R. E. | en_US |
dc.contributor.author | Gelrud, A. | en_US |
dc.contributor.author | Banks, P. A. | en_US |
dc.contributor.author | Sherman, S. | en_US |
dc.contributor.author | Anderson, M. A. | en_US |
dc.contributor.author | Romagnuolo, J. | en_US |
dc.contributor.author | Lawrence, C. | en_US |
dc.contributor.author | Baillie, J. | en_US |
dc.contributor.author | Gardner, T. B. | en_US |
dc.contributor.author | Lewis, M. D. | en_US |
dc.contributor.author | Amann, S. T. | en_US |
dc.contributor.author | Lieb, J. G. | en_US |
dc.contributor.author | O’connell, M. | en_US |
dc.contributor.author | Kennard, E. D. | en_US |
dc.contributor.author | Yadav, D. | en_US |
dc.contributor.author | Whitcomb, David C. | en_US |
dc.contributor.author | Forsmark, C. E. | en_US |
dc.date.accessioned | 2011-01-31T17:29:57Z | |
dc.date.available | 2012-03-05T15:30:01Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Burton, F.; Alkaade, S.; Collins, D.; Muddana, V.; Slivka, A.; Brand, R. E.; Gelrud, A.; Banks, P. A.; Sherman, S.; Anderson, M. A.; Romagnuolo, J.; Lawrence, C.; Baillie, J.; Gardner, T. B.; Lewis, M. D.; Amann, S. T.; Lieb, J. G.; O’connell, M.; Kennard, E. D.; Yadav, D.; Whitcomb, D. C.; Forsmark, C. E.; (2011). "Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States." Alimentary Pharmacology & Therapeutics 33(1): 149-159. <http://hdl.handle.net/2027.42/79114> | en_US |
dc.identifier.issn | 0269-2813 | en_US |
dc.identifier.issn | 1365-2036 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79114 | |
dc.description.abstract | Aliment Pharmacol Ther 2011; 33: 149–159Effectiveness of medical therapies in chronic pancreatitis has been described in small studies of selected patients.To describe frequency and perceived effectiveness of non-analgesic medical therapies in chronic pancreatitis patients evaluated at US referral centres.Using data on 516 chronic pancreatitis patients enrolled prospectively in the NAPS2 Study, we evaluated how often medical therapies [pancreatic enzyme replacement therapy (PERT), vitamins/antioxidants (AO), octreotide, coeliac plexus block (CPB)] were utilized and considered useful by physicians.Oral PERT was commonly used (70%), more frequently in the presence of exocrine insufficiency (EI) (88% vs. 61%, P < 0.001) and pain (74% vs. 59%, P < 0.002). On multivariable analyses, predictors of PERT usage were EI (OR 5.14, 95% CI 2.87–9.18), constant (OR 3.42, 95% CI 1.93–6.04) or intermittent pain (OR 1.98, 95% CI 1.14–3.45). Efficacy of PERT was predicted only by EI (OR 2.16, 95% CI 1.36–3.42). AO were tried less often (14%) and were more effective in idiopathic and obstructive vs. alcoholic chronic pancreatitis (25% vs. 4%, P = 0.03). Other therapies were infrequently used (CPB – 5%, octreotide – 7%) with efficacy generally <50%.Pancreatic enzyme replacement therapy is commonly utilized, but is considered useful in only subsets of chronic pancreatitis patients. Other medical therapies are used infrequently and have limited efficacy. | en_US |
dc.format.extent | 139103 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.title | Use and perceived effectiveness of non-analgesic medical therapies for chronic pancreatitis in the United States | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbsecondlevel | Pharmacy and Pharmacology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Ann Arbor, MI, USA. | en_US |
dc.contributor.affiliationother | St. Louis University, St. Louis, MO, USA. | en_US |
dc.contributor.affiliationother | University of Florida, Gainesville, FL, USA. | en_US |
dc.contributor.affiliationother | University of Pittsburgh, Pittsburgh, PA, USA. | en_US |
dc.contributor.affiliationother | Brigham and Women’s Hospital, Boston, MA, USA. | en_US |
dc.contributor.affiliationother | Indiana University Medical Center, Indianapolis, IN, USA. | en_US |
dc.contributor.affiliationother | Digestive Disease Center, Medical University of South Carolina, Charleston, SC, USA. | en_US |
dc.contributor.affiliationother | Duke University Medical Center, Durham, NC, USA. | en_US |
dc.contributor.affiliationother | Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA. | en_US |
dc.contributor.affiliationother | Mayo Clinic, Jacksonville, FL, USA. | en_US |
dc.contributor.affiliationother | North Mississippi Medical Center, Tupelo, MS, USA. | en_US |
dc.contributor.affiliationother | University of Pennsylvania School of Medicine, Philadelphia, PA, USA. | en_US |
dc.contributor.affiliationother | Epidemiology Data Center, University of Pittsburgh, Pittsburgh, PA, USA. | en_US |
dc.identifier.pmid | 21083584 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79114/1/j.1365-2036.2010.04491.x.pdf | |
dc.identifier.doi | 10.1111/j.1365-2036.2010.04491.x | en_US |
dc.identifier.source | Alimentary Pharmacology & Therapeutics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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