Extracorporeal Support: Improves Donor Renal Graft Function After Cardiac Death
dc.contributor.author | Rojas-Pena, A. | en_US |
dc.contributor.author | Reoma, J. L. | en_US |
dc.contributor.author | Krause, E. | en_US |
dc.contributor.author | Boothman, E. L. | en_US |
dc.contributor.author | Padiyar, N. P. | en_US |
dc.contributor.author | Cook, K. E. | en_US |
dc.contributor.author | Bartlett, Robert H. | en_US |
dc.contributor.author | Punch, Jeffery D. | en_US |
dc.date.accessioned | 2011-01-31T17:35:38Z | |
dc.date.available | 2011-08-02T18:19:14Z | en_US |
dc.date.issued | 2010-06 | en_US |
dc.identifier.citation | Rojas-Pena, A.; Reoma, J. L.; Krause, E.; Boothman, E. L.; Padiyar, N. P.; Cook, K. E.; Bartlett, R. H.; Punch, J. D.; (2010). "Extracorporeal Support: Improves Donor Renal Graft Function After Cardiac Death." American Journal of Transplantation 10(6): 1365-1374. <http://hdl.handle.net/2027.42/79164> | en_US |
dc.identifier.issn | 1600-6135 | en_US |
dc.identifier.issn | 1600-6143 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79164 | |
dc.description.abstract | Donors after cardiac death (DCD) could increase the organ pool. Data supports good long-term renal graft survival. However, DCDs are <10% of deceased donors in the United States, due to delayed graft function, and primary nonfunction. These complications are minimized by extracorporeal support after cardiac death (ECS-DCD). This study assesses immediate and acute renal function from different donor types. DCDs kidneys were recovered by conventional rapid recovery or by ECS, and transplanted into nephrectomized healthy swine. Warm ischemia of 10 and 30 min were evaluated. Swine living donors were controls (LVD). ECS-DCDs were treated with 90 min of perfusion until organ recovery. After procurement, kidneys were cold storage 4–6 h. Renal vascular resistance (RVR), urine output (UO), urine protein concentration (UrPr) and creatinine clearance (CrCl), were collected during 4 h posttransplantation. All grafts functioned with adequate renal blood flow for 4 h. RVR at 4 h posttransplant returned to baseline only in the LVD group (0.36 mmHg/mL/min ± 0.03). RVR was higher in all DCDs (0.66 mmHg/mL/min ± 0.13), without differences between them. UO was >50 mL/h in all DCDs, except in DCD-30 (6.8 mL/h ± 1.7). DCD-30 had lower CrCl (0.9 mL/min ± 0.2) and higher UrPr >200 mg/dL, compared to other DCDs >10 mL/min and <160 mg/dL, respectively. Normothermic ECS can resuscitate kidneys to transplantable status after 30 min of cardiac arrest/WI. | en_US |
dc.format.extent | 513770 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.subject.other | Donor Pool | en_US |
dc.subject.other | Donor Preconditioning | en_US |
dc.subject.other | Early Graft Function | en_US |
dc.subject.other | Experimental Models | en_US |
dc.subject.other | Extracorporeal Membrane Oxygenation | en_US |
dc.subject.other | Graft Function | en_US |
dc.subject.other | Injury and Preservation | en_US |
dc.subject.other | Ischemia Time | en_US |
dc.subject.other | Kidney Graft Function | en_US |
dc.subject.other | Kidney | en_US |
dc.subject.other | Large Animal Model | en_US |
dc.subject.other | Nonbeating Heart Donor | en_US |
dc.subject.other | Normothermic Recirculation | en_US |
dc.subject.other | Organ and Tissue Procurement | en_US |
dc.subject.other | Organ Storage | en_US |
dc.title | Extracorporeal Support: Improves Donor Renal Graft Function After Cardiac Death | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | General Surgery Department, Division of Transplantation, University of Michigan Health System, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | General Surgery Department, Extracorporeal Life Support (ECS) Laboratory, University of Michigan Health System, Ann Arbor, MI | en_US |
dc.identifier.pmid | 20553447 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79164/1/j.1600-6143.2010.03063.x.pdf | |
dc.identifier.doi | 10.1111/j.1600-6143.2010.03063.x | en_US |
dc.identifier.source | American Journal of Transplantation | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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