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Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy
dc.contributor.authorRosenberg, Philip S.en_US
dc.contributor.authorZeidler, Corneliaen_US
dc.contributor.authorBolyard, Audrey Annaen_US
dc.contributor.authorAlter, Blanche P.en_US
dc.contributor.authorBonilla, Mary A.en_US
dc.contributor.authorBoxer, Laurence A.en_US
dc.contributor.authorDror, Yigalen_US
dc.contributor.authorKinsey, Sallyen_US
dc.contributor.authorLink, Daniel C.en_US
dc.contributor.authorNewburger, Peter E.en_US
dc.contributor.authorShimamura, Akikoen_US
dc.contributor.authorWelte, Karlen_US
dc.contributor.authorDale, David C.en_US
dc.date.accessioned2011-01-31T17:47:01Z
dc.date.available2011-09-06T16:03:05Zen_US
dc.date.issued2010-07en_US
dc.identifier.citationRosenberg, Philip S.; Zeidler, Cornelia; Bolyard, Audrey A.; Alter, Blanche P.; Bonilla, Mary A.; Boxer, Laurence A.; Dror, Yigal; Kinsey, Sally; Link, Daniel C.; Newburger, Peter E.; Shimamura, Akiko; Welte, Karl; Dale, David C.; (2010). "Stable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapy." British Journal of Haematology 150(2): 196-199. <http://hdl.handle.net/2027.42/79264>en_US
dc.identifier.issn0007-1048en_US
dc.identifier.issn1365-2141en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/79264
dc.description.abstractIn severe congenital neutropenia (SCN), long-term therapy with granulocyte colony-stimulating factor (G-CSF) has reduced mortality from sepsis, revealing an underlying predisposition to myelodysplastic syndrome and acute myeloid leukaemia (MDS/AML). We have reported the early pattern of evolution to MDS/AML, but the long-term risk remains uncertain. We updated a prospective study of 374 SCN patients on long-term G-CSF enrolled in the Severe Chronic Neutropenia International Registry. Long-term, the annual risk of MDS/AML attained a plateau (2·3%/year after 10 years). This risk now appears similar to, rather than higher than, the risk of AML in Fanconi anaemia and dyskeratosis congenita.en_US
dc.format.extent187310 bytes
dc.format.extent3106 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Ltden_US
dc.subject.otherSevere Congenital Neutropeniaen_US
dc.subject.otherAcute Myeloid Leukaemiaen_US
dc.subject.otherMyelodysplastic Syndromesen_US
dc.subject.otherGranulocyte Colony-stimulating Factoren_US
dc.titleStable long-term risk of leukaemia in patients with severe congenital neutropenia maintained on G-CSF therapyen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan, Pediatric Hematology/Oncology, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherBiostatistics Branch, National Cancer Institute, Rockville, MD, USAen_US
dc.contributor.affiliationotherKinderklinik, Medizinische Hochschule, Carl-Neuberg-Str. 1, Hannover, Germanyen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Washington, Seattle, WAen_US
dc.contributor.affiliationotherClinical Genetics Branch, National Cancer Institute, Rockville, MDen_US
dc.contributor.affiliationotherSt. Joseph’s Children’s Hospital, Pediatric Hematology Oncology, Paterson NJen_US
dc.contributor.affiliationotherHospital for Sick Children, The University of Toronto, Toronto, ON, Canadaen_US
dc.contributor.affiliationotherPaediatric Haematology, St. James’s University Hospital, Leeds, UKen_US
dc.contributor.affiliationotherWashington University School of Medicine, Division of Bone Marrow Transplantation, St. Louis, MOen_US
dc.contributor.affiliationotherUniversity of Massachusetts Medical School, Worcester, MAen_US
dc.contributor.affiliationotherFred Hutchinson Cancer Research Center, Seattle, WA, USAen_US
dc.identifier.pmid20456363en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/79264/1/j.1365-2141.2010.08216.x.pdf
dc.identifier.doi10.1111/j.1365-2141.2010.08216.xen_US
dc.identifier.sourceBritish Journal of Haematologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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