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Are Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?

dc.contributor.authorKato, Hiroshien_US
dc.contributor.authorFox, David A.en_US
dc.date.accessioned2011-01-31T17:50:36Z
dc.date.available2012-02-21T18:47:01Zen_US
dc.date.issued2010-12en_US
dc.identifier.citationKato, Hiroshi; Fox, David A.; (2010). "Are Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?." Clinical and Translational Science 3(6): 319-326. <http://hdl.handle.net/2027.42/79296>en_US
dc.identifier.issn1752-8054en_US
dc.identifier.issn1752-8062en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/79296
dc.description.abstractTh17 cells play crucial roles not only in host defense but also in many human autoimmune diseases and corresponding animal models. Although many of the fundamental principles regarding Th17 biology have been rapidly elucidated in mice, there remain numerous controversies regarding the differentiation, plasticity, and pathogenicity of human Th17 cells. In this review, we consider these open questions in comparison to what has already been clarified in mice, and discuss the potential impact of discoveries related to the Th17 pathway on the development of new therapeutic strategies in Th17 driven autoimmune diseases, specifically rheumatoid arthritis. Clin Trans Sci 2010; Volume 3: 319–326en_US
dc.format.extent788230 bytes
dc.format.extent3106 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherBlackwell Publishing Incen_US
dc.subject.otherLymphocytesen_US
dc.subject.otherRheumatologyen_US
dc.subject.otherCytokinesen_US
dc.subject.otherTranslational Researchen_US
dc.titleAre Th17 Cells an Appropriate New Target in the Treatment of Rheumatoid Arthritis?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelPharmacy and Pharmacologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumUniversity of Michigan Health System, Department of Internal Medicine, Division of Rheumatology, Ann Arbor, Michigan, USA.en_US
dc.identifier.pmid21167010en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/79296/1/j.1752-8062.2010.00233.x.pdf
dc.identifier.doi10.1111/j.1752-8062.2010.00233.xen_US
dc.identifier.sourceClinical and Translational Scienceen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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