Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection
dc.contributor.author | Machado, Eleuza R. | en_US |
dc.contributor.author | Carlos, Daniela | en_US |
dc.contributor.author | Lourenço, Elaine V. | en_US |
dc.contributor.author | Souza, Glória E. P. | en_US |
dc.contributor.author | Sorgi, Carlos A. | en_US |
dc.contributor.author | Silva, Érika V. | en_US |
dc.contributor.author | Ueta, Marlene T. | en_US |
dc.contributor.author | Ramos, Simone G. | en_US |
dc.contributor.author | Aronoff, David M. | en_US |
dc.contributor.author | Faccioli, Lúcia H. | en_US |
dc.date.accessioned | 2011-01-31T17:50:43Z | |
dc.date.available | 2011-08-02T18:19:14Z | en_US |
dc.date.issued | 2010-06 | en_US |
dc.identifier.citation | Machado, Eleuza R.; Carlos, Daniela; Lourenço, Elaine V.; Souza, Glória E.P.; Sorgi, Carlos A.; Silva, Érika V.; Ueta, Marlene T.; Ramos, Simone G.; Aronoff, David M.; Faccioli, Lúcia H.; (2010). "Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection." FEMS Immunology & Medical Microbiology 59(1): 18-32. <http://hdl.handle.net/2027.42/79297> | en_US |
dc.identifier.issn | 0928-8244 | en_US |
dc.identifier.issn | 1574-695X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79297 | |
dc.description.abstract | The aim of this study was to define the immunoregulatory role of prostaglandins in a mouse model of Strongyloides venezuelensis infection. Strongyloides venezuelensis induced an increase of eosinophils and mononuclear cells in the blood, peritoneal cavity fluid, and bronchoalveolar lavage fluid. Treatment with the dual cyclooxygenase (COX-1/-2) inhibitors indomethacin and ibuprofen, and the COX-2-selective inhibitor celecoxib partially blocked these cellular responses and was associated with enhanced numbers of infective larvae in the lung and adult worms in the duodenum. However, the drugs did not interfere with worm fertility. Cyclooxygenase inhibitors also inhibited the production of the T-helper type 2 (Th2) mediators IL-5, IgG1, and IgE, while indomethacin alone also inhibited IL-4, IL-10, and IgG2a. Cyclooxygenase inhibitors tended to enhance the Th1 mediators IL-12 and IFN-γ. This shift away from Th2 immunity in cyclooxygenase inhibitor-treated mice correlated with reduced prostaglandin E 2 (PGE 2 ) production in infected duodenal tissue. As PGE 2 is a well-characterized driver of Th2 immunity, we speculate that reduced production of this lipid might be involved in the shift toward a Th1 phenotype, favoring parasitism by S. venezuelensis . These findings provide new evidence that cyclooxygenase-derived lipids play a role in regulating host defenses against Strongyloides , and support the exploration of eicosanoid signaling for identifying novel preventive and therapeutic modalities against these infections. | en_US |
dc.format.extent | 3017771 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.subject.other | Immune Response | en_US |
dc.subject.other | Strongyloides Venezuelensis | en_US |
dc.subject.other | PGE 2 | en_US |
dc.subject.other | Eosinophils | en_US |
dc.subject.other | Cytokine | en_US |
dc.subject.other | Antibody | en_US |
dc.title | Cyclooxygenase-derived mediators regulate the immunological control of Strongyloides venezuelensis infection | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Infectious Diseases, Graduate Program in Immunology, University of Michigan Health System, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil | en_US |
dc.contributor.affiliationother | Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, São Paulo, Brazil | en_US |
dc.contributor.affiliationother | Instituto de Biologia, Universidade Estadual de Campinas, São Paulo, Brazil | en_US |
dc.identifier.pmid | 20236322 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79297/1/j.1574-695X.2010.00656.x.pdf | |
dc.identifier.doi | 10.1111/j.1574-695X.2010.00656.x | en_US |
dc.identifier.source | FEMS Immunology & Medical Microbiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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