View Item 

Show simple item record

Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism

dc.contributor.authorChiu, Hsiu-Juen_US
dc.contributor.authorBakolitsa, Constantinaen_US
dc.contributor.authorSkerra, Arneen_US
dc.contributor.authorLomize, Andrei L.en_US
dc.contributor.authorCarlton, Dennisen_US
dc.contributor.authorMiller, Mitchell D.en_US
dc.contributor.authorKrishna, S. Srien_US
dc.contributor.authorAbdubek, Polaten_US
dc.contributor.authorAstakhova, Tamaraen_US
dc.contributor.authorAxelrod, Herbert L.en_US
dc.contributor.authorClayton, Thomasen_US
dc.contributor.authorDeller, Marc C.en_US
dc.contributor.authorDuan, Lianen_US
dc.contributor.authorFeuerhelm, Julieen_US
dc.contributor.authorGrant, Joanna C.en_US
dc.contributor.authorGrzechnik, Slawomir K.en_US
dc.contributor.authorHan, Gye Wonen_US
dc.contributor.authorJaroszewski, Lukaszen_US
dc.contributor.authorJin, Kevin K.en_US
dc.contributor.authorKlock, Heath E.en_US
dc.contributor.authorKnuth, Mark W.en_US
dc.contributor.authorKozbial, Piotren_US
dc.contributor.authorKumar, Abhinaven_US
dc.contributor.authorMarciano, Daviden_US
dc.contributor.authorMcmullan, Danielen_US
dc.contributor.authorMorse, Andrew T.en_US
dc.contributor.authorNigoghossian, Edwarden_US
dc.contributor.authorOkach, Lindaen_US
dc.contributor.authorPaulsen, Jessicaen_US
dc.contributor.authorReyes, Ronen_US
dc.contributor.authorRife, Christopher L.en_US
dc.contributor.authorVan Den Bedem, Henryen_US
dc.contributor.authorWeekes, Danaen_US
dc.contributor.authorXu, Qingpingen_US
dc.contributor.authorHodgson, Keith O.en_US
dc.contributor.authorWooley, Johnen_US
dc.contributor.authorElsliger, Marc-Andréen_US
dc.contributor.authorDeacon, Ashley M.en_US
dc.contributor.authorGodzik, Adamen_US
dc.contributor.authorLesley, Scott A.en_US
dc.contributor.authorWilson, Ian A.en_US
dc.date.accessioned2011-01-31T17:56:28Z
dc.date.available2011-12-02T15:41:52Zen_US
dc.date.issued2010-10-01en_US
dc.identifier.citationChiu, Hsiu-Ju; Bakolitsa, Constantina; Skerra, Arne; Lomize, Andrei; Carlton, Dennis; Miller, Mitchell D.; Krishna, S. Sri; Abdubek, Polat; Astakhova, Tamara; Axelrod, Herbert L.; Clayton, Thomas; Deller, Marc C.; Duan, Lian; Feuerhelm, Julie; Grant, Joanna C.; Grzechnik, Slawomir K.; Han, Gye Won; Jaroszewski, Lukasz; Jin, Kevin K.; Klock, Heath E.; Knuth, Mark W.; Kozbial, Piotr; Kumar, Abhinav; Marciano, David; Mcmullan, Daniel; Morse, Andrew T.; Nigoghossian, Edward; Okach, Linda; Paulsen, Jessica; Reyes, Ron; Rife, Christopher L.; Van Den Bedem, Henry; Weekes, Dana; Xu, Qingping; Hodgson, Keith O.; Wooley, John; Elsliger, Marc-André; Deacon, Ashley M.; Godzik, Adam; Lesley, Scott A.; Wilson, Ian A.; (2010). "Structure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolism." Acta Crystallographica Section F 66(10): 1153-1159. <http://hdl.handle.net/2027.42/79347>en_US
dc.identifier.issn1744-3091en_US
dc.identifier.issn1744-3091en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/79347
dc.description.abstractThe first structural representative of the domain of unknown function DUF2006 family, also known as Pfam family PF09410, comprises a lipocalin-like fold with domain duplication. The finding of the calycin signature in the N-terminal domain, combined with remote sequence similarity to two other protein families (PF07143 and PF08622) implicated in isoprenoid metabolism and the oxidative stress response, support an involvement in lipid metabolism. Clusters of conserved residues that interact with ligand mimetics suggest that the binding and regulation sites map to the N-terminal domain and to the interdomain interface, respectively.en_US
dc.format.extent1362447 bytes
dc.format.extent3106 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherInternational Union of Crystallographyen_US
dc.publisherBlackwell Publishing Ltden_US
dc.subject.otherStructural Genomicsen_US
dc.subject.otherDomains of Unknown Functionen_US
dc.subject.otherCalycinen_US
dc.subject.otherLipocalinen_US
dc.subject.otherFatty-acid Binding Proteinsen_US
dc.titleStructure of the first representative of Pfam family PF09410 (DUF2006) reveals a structural signature of the calycin superfamily that suggests a role in lipid metabolismen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelBiological Chemistryen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109-1065, USAen_US
dc.contributor.affiliationotherJoint Center for Structural Genomics, http://www.jcsg.org , USAen_US
dc.contributor.affiliationotherStanford Synchrotron Radiation Lightsource, SLAC National Accelerator Laboratory, Menlo Park, CA, USAen_US
dc.contributor.affiliationotherProgram on Bioinformatics and Systems Biology, Burnham Institute for Medical Research, La Jolla, CA, USAen_US
dc.contributor.affiliationotherLehrstuhl für Biologische Chemie, Technische Universität München, 85350 Freizing-Weihenstephan, Germanyen_US
dc.contributor.affiliationotherDepartment of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USAen_US
dc.contributor.affiliationotherCenter for Research in Biological Systems, University of California, San Diego, La Jolla, CA, USAen_US
dc.contributor.affiliationotherProtein Sciences Department, Genomics Institute of the Novartis Research Foundation, San Diego, CA, USAen_US
dc.contributor.affiliationotherPhoton Science, SLAC National Accelerator Laboratory, Menlo Park, CA, USAen_US
dc.identifier.pmid20944205en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/79347/1/S1744309109037749.pdf
dc.identifier.doi10.1107/S1744309109037749en_US
dc.identifier.sourceActa Crystallographica Section Fen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Name:
S1744309109037749.pdf
Size:
1.299MB
Format:
PDF
View/Open

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.