Bedside-to-Bench Conference: Research Agenda for Idiopathic Fatigue and Aging
dc.contributor.author | Alexander, Neil B. | en_US |
dc.contributor.author | Taffet, George E. | en_US |
dc.contributor.author | Horne, Frances Mcfarland | en_US |
dc.contributor.author | Eldadah, Basil A. | en_US |
dc.contributor.author | Ferrucci, Luigi | en_US |
dc.contributor.author | Nayfield, Susan G. | en_US |
dc.contributor.author | Studenski, Stephanie | en_US |
dc.date.accessioned | 2011-01-31T17:59:02Z | |
dc.date.available | 2011-07-05T19:03:08Z | en_US |
dc.date.issued | 2010-05 | en_US |
dc.identifier.citation | Alexander, Neil B.; Taffet, George E.; Horne, Frances Mcfarland; Eldadah, Basil A.; Ferrucci, Luigi; Nayfield, Susan; Studenski, Stephanie; (2010). "Bedside-to-Bench Conference: Research Agenda for Idiopathic Fatigue and Aging." Journal of the American Geriatrics Society 58(5): 967-975. <http://hdl.handle.net/2027.42/79370> | en_US |
dc.identifier.issn | 0002-8614 | en_US |
dc.identifier.issn | 1532-5415 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79370 | |
dc.description.abstract | The American Geriatrics Society, with support from the National Institute on Aging and the John A. Hartford Foundation, held its fifth Bedside-to-Bench research conference, “Idiopathic Fatigue and Aging,” to provide participants with opportunities to learn about cutting-edge research developments, draft recommendations for future research, and network with colleagues and leaders in the field.Fatigue is a symptom that older persons, especially by those with chronic diseases, frequently experience. Definitions and prevalence of fatigue may vary across studies, across diseases, and even between investigators and patients. The focus of this review is on physical fatigue, recognizing that there are other related domains of fatigue (such as cognitive fatigue).Many definitions of fatigue involve a sensation of “low” energy, suggesting that fatigue could be a disorder of energy balance. Poor energy utilization efficiency has not been considered in previous studies but is likely to be one of the most important determinants of fatigue in older individuals. Relationships between activity level, capacity for activity, a tolerable rate of activity, and a tolerable fatigue threshold or ceiling underlie a notion of fatiguability. Mechanisms probably contributing to fatigue in older adults include decline in mitochondrial function, alterations in brain neurotransmitters, oxidative stress, and inflammation. The relationships between muscle function and fatigue are complex. A number of diseases (such as cancer) are known to cause fatigue and may serve as models for how underlying impaired physiological processes contribute to fatigue, particularly those in which energy utilization may be an important factor. A further understanding of fatigue will require two key strategies: to develop and refine fatigue definitions and measurement tools and to explore underlying mechanisms using animal and human models. | en_US |
dc.format.extent | 167690 bytes | |
dc.format.extent | 3106 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Blackwell Publishing Inc | en_US |
dc.subject.other | Fatigue | en_US |
dc.subject.other | Energy Utilization | en_US |
dc.subject.other | Mitochondria | en_US |
dc.subject.other | Muscle | en_US |
dc.title | Bedside-to-Bench Conference: Research Agenda for Idiopathic Fatigue and Aging | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Geriatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Mobility Research Center, Geriatrics Center and Division of Geriatric Medicine, University of Michigan Hospitals and Veterans Affairs Ann Arbor Health Care System Geriatric Research Education and Clinical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Baylor College of Medicine, Methodist Hospital, Houston, Texas | en_US |
dc.contributor.affiliationother | American Geriatrics Society, New York, New York | en_US |
dc.contributor.affiliationother | Division of Geriatrics and Clinical Gerontology, National Institute on Aging, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | Geriatric Research, Education and Clinical Center, Department of Veterans Affairs Pittsburgh Healthcare Center, Pittsburgh, Pennsylvania. | en_US |
dc.identifier.pmid | 20722821 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79370/1/j.1532-5415.2010.02811.x.pdf | |
dc.identifier.doi | 10.1111/j.1532-5415.2010.02811.x | en_US |
dc.identifier.source | Journal of the American Geriatrics Society | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.