Novel Double Lumen Catheter for Drug Delivery at the Skin- Catheter Interface
dc.contributor.author | Peramo, Antonio | |
dc.date.accessioned | 2011-01-31T22:38:02Z | |
dc.date.available | 2011-01-31T22:38:02Z | |
dc.date.issued | 2010-11-08 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/79405 | |
dc.description.abstract | This paper shows the technical feasibility of using a modified double lumen catheter for the delivery of fluids at the skin-catheter interface in an in vivo rabbit model. The modified catheter permits the extrusion of suspensions at the site of contact between the skin and the modified catheter (exit site). The modification consisted in the addition of a second lumen, exterior to the original one of the catheter and of shorter length, ending in an extrusion port placed sub dermally. An external fluid pump was attached to the catheter and the whole system was tested in vitro in human skin, in a cadaver model and in an in vivo rabbit model. Experiments were performed by delivering solutions of methylene blue in a controlled manner to the subcutaneous area to analyze the skin response to the process. Results indicate that this technique of pumping the material is effective in producing observable epithelial changes in the short term. The modification of the catheter addresses catheter exit site lack of integration of skin and works as a model that can be implemented in a number of percutaneous devices for long-term implantation. | en_US |
dc.description.sponsorship | Medical Innovation Center of the University of Michigan | en_US |
dc.format.extent | 3877838 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | OMICs Publishing Group | en_US |
dc.subject | Percutaneous; Skin Biomaterial; Double Lumen; Bio Integration | en_US |
dc.title | Novel Double Lumen Catheter for Drug Delivery at the Skin- Catheter Interface | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Dentistry | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Dentistry, School of | en_US |
dc.contributor.affiliationum | Department of Oral and Maxillofacial surgery | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79405/1/peramo-catheter.pdf | |
dc.identifier.doi | 10.4172/2157-7552.1000102 | |
dc.identifier.source | Journal of Tissue Science and Engineering | en_US |
dc.owningcollname | Dentistry, School of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.