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Novel Double Lumen Catheter for Drug Delivery at the Skin- Catheter Interface

dc.contributor.authorPeramo, Antonio
dc.date.accessioned2011-01-31T22:38:02Z
dc.date.available2011-01-31T22:38:02Z
dc.date.issued2010-11-08
dc.identifier.urihttps://hdl.handle.net/2027.42/79405
dc.description.abstractThis paper shows the technical feasibility of using a modified double lumen catheter for the delivery of fluids at the skin-catheter interface in an in vivo rabbit model. The modified catheter permits the extrusion of suspensions at the site of contact between the skin and the modified catheter (exit site). The modification consisted in the addition of a second lumen, exterior to the original one of the catheter and of shorter length, ending in an extrusion port placed sub dermally. An external fluid pump was attached to the catheter and the whole system was tested in vitro in human skin, in a cadaver model and in an in vivo rabbit model. Experiments were performed by delivering solutions of methylene blue in a controlled manner to the subcutaneous area to analyze the skin response to the process. Results indicate that this technique of pumping the material is effective in producing observable epithelial changes in the short term. The modification of the catheter addresses catheter exit site lack of integration of skin and works as a model that can be implemented in a number of percutaneous devices for long-term implantation.en_US
dc.description.sponsorshipMedical Innovation Center of the University of Michiganen_US
dc.format.extent3877838 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.publisherOMICs Publishing Groupen_US
dc.subjectPercutaneous; Skin Biomaterial; Double Lumen; Bio Integrationen_US
dc.titleNovel Double Lumen Catheter for Drug Delivery at the Skin- Catheter Interfaceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelDentistry
dc.subject.hlbtoplevelHealth Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDentistry, School ofen_US
dc.contributor.affiliationumDepartment of Oral and Maxillofacial surgeryen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/79405/1/peramo-catheter.pdf
dc.identifier.doi10.4172/2157-7552.1000102
dc.identifier.sourceJournal of Tissue Science and Engineeringen_US
dc.owningcollnameDentistry, School of


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