Polysorbate cationic synthetic vesicle for gene delivery
dc.contributor.author | Huang, Yongzhuo | en_US |
dc.contributor.author | Rao, Yuefeng | en_US |
dc.contributor.author | Chen, Jinliang | en_US |
dc.contributor.author | Yang, Victor C. | en_US |
dc.contributor.author | Liang, Wenquan | en_US |
dc.date.accessioned | 2011-02-02T18:00:15Z | |
dc.date.available | 2012-04-03T21:46:58Z | en_US |
dc.date.issued | 2011-03-01 | en_US |
dc.identifier.citation | Huang, Yongzhuo; Rao, Yuefeng; Chen, Jinliang; Yang, Victor C.; Liang, Wenquan (2011). "Polysorbate cationic synthetic vesicle for gene delivery." Journal of Biomedical Materials Research Part A 96A(3): 513-519. <http://hdl.handle.net/2027.42/79430> | en_US |
dc.identifier.issn | 1549-3296 | en_US |
dc.identifier.issn | 1552-4965 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79430 | |
dc.description.abstract | Synthetic nonionic surfactant vesicles (niosomes) are a colloidal system with closed bilayer structures, displaying distinct advantages in stability and cost compared with liposomes. In this article, polysorbate cationic niosomes (PCNs) were developed as gene carriers. The PCNs comprised nonionic surfactants (i.e., polysorbates) and a cationic cholesterol, and were synthesized using a film hydration method. The niosomes thus prepared possessed a regular morphology, and a particle size of 100 ∼ 200 nm, and a zeta potential of +30 ∼ 45 mV. The PCNs showed great physical stability over the course of 4 weeks at room temperature. The binding capacity of PCNs toward oligodeoxynucleotides (ODN) was assessed by a gel retardation approach, which demonstrated that the ionic complexes were formed when ± charge ratio reached to 4 or greater. Gene transfer study showed that the PCNs exhibited a high efficiency in mediating cellular uptake and transferred DNA expression. Based on these findings, PCNs may offer the potential to function as an effective gene delivery system. © 2011 Wiley Periodicals, Inc. J Biomed Mater Res Part A:, 2011. | en_US |
dc.format.extent | 455226 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Polysorbate cationic synthetic vesicle for gene delivery | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Hai-ke Road, Shanghai, 201203, China ; College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationum | College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109 ; College of Pharmacy, University of Michigan, 428 Church Street, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | The First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, China | en_US |
dc.contributor.affiliationother | The First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, China | en_US |
dc.contributor.affiliationother | The First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, China ; The First Affiliated Hospital, College of Medicine, and College of Pharmaceutical Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, 310058, China | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79430/1/32999_ftp.pdf | |
dc.identifier.doi | 10.1002/jbm.a.32999 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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