Structure and Function of Histone H3 Lysine 9 Methyltransferases and Demethylases
dc.contributor.author | Krishnan , Swathi | en_US |
dc.contributor.author | Horowitz , Scott | en_US |
dc.contributor.author | Trievel, Raymond C. | en_US |
dc.date.accessioned | 2011-02-02T18:00:21Z | |
dc.date.available | 2012-02-21T18:47:01Z | en_US |
dc.date.issued | 2011-01-24 | en_US |
dc.identifier.citation | Krishnan , Swathi; Horowitz , Scott; Trievel, Raymond C. (2011). "Structure and Function of Histone H3 Lysine 9 Methyltransferases and Demethylases." ChemBioChem 12(2): 254-263. <http://hdl.handle.net/2027.42/79431> | en_US |
dc.identifier.issn | 1439-4227 | en_US |
dc.identifier.issn | 1439-7633 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/79431 | |
dc.description.abstract | Histone lysine methylation is a dynamic chromatin modification that plays key regulatory roles in gene expression and other genomic functions. Methylation of Lys9 in histone H3 (H3K9) is a prominent modification that has been implicated in diverse processes, including transcriptional silencing, heterochromatin formation, and DNA methylation. In this review, we summarize recent advances in understanding the structure and substrate specificity of the H3K9-specific methyltransferases G9A and GLP and explore current efforts to develop inhibitors of these enzymes. In addition, we discuss the structure and specificity of the recently discovered PHF8 family of histone demethylases that target H3K9 as well as other methylation sites in histones H3 and H4. Finally, we conclude by comparing the H3K9 binding modes displayed by these enzymes and examine the relevance of these studies to their biological functions and to structure-based inhibitor design. | en_US |
dc.format.extent | 834283 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biochemistry and Biotechnology | en_US |
dc.title | Structure and Function of Histone H3 Lysine 9 Methyltransferases and Demethylases | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Department of Biological Chemistry, 1150 West Medical Center Drive, 4315 Medical Science Research Building III, Ann Arbor, MI 48109 (USA) ; These authors contributed equally to this work. | en_US |
dc.contributor.affiliationum | University of Michigan, Biophysics Graduate Program, Ann Arbor, MI 48109 (USA) | en_US |
dc.contributor.affiliationum | University of Michigan Medical School, Department of Biological Chemistry, 1150 West Medical Center Drive, 5301 Medical Science Research Building III, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-763-4581 ; University of Michigan Medical School, Department of Biological Chemistry, 1150 West Medical Center Drive, 5301 Medical Science Research Building III, Ann Arbor, MI 48109 (USA), Fax: (+1) 734-763-4581 | en_US |
dc.identifier.pmid | 21243713 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/79431/1/254_ftp.pdf | |
dc.identifier.doi | 10.1002/cbic.201000545 | en_US |
dc.identifier.source | ChemBioChem | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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