Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication
dc.contributor.author | Vlangos, Christopher N. | en_US |
dc.contributor.author | Siuniak, Amanda | en_US |
dc.contributor.author | Ackley, Todd | en_US |
dc.contributor.author | van Bokhoven, Hans | en_US |
dc.contributor.author | Veltman, Joris | en_US |
dc.contributor.author | Iyer, Ramaswamy K. | en_US |
dc.contributor.author | Park, John M. | en_US |
dc.contributor.author | Keppler-Noreuil, Kim | en_US |
dc.contributor.author | Keegan, Catherine E. | en_US |
dc.date.accessioned | 2011-03-10T16:02:43Z | |
dc.date.accessioned | 2011-03-10T16:02:43Z | |
dc.date.available | 2012-02-21T18:47:00Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Vlangos, Christopher N.; Siuniak, Amanda; Ackley, Todd; van Bokhoven, Hans; Veltman, Joris; Iyer, Ram; Park, John M.; Keppler-Noreuil, Kim; Keegan, Catherine E. (2011). "Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication." American Journal of Medical Genetics Part A 155(1): 38-49. <http://hdl.handle.net/2027.42/83173> | en_US |
dc.identifier.issn | 1552-4825 | en_US |
dc.identifier.issn | 1552-4833 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83173 | |
dc.description.abstract | Omphalocele–exstrophy of the bladder-imperforate anus-spinal defects (OEIS) complex, or cloacal exstrophy (EC), is a rare constellation of malformations in humans involving the urogenital, gastrointestinal, and skeletal systems, and less commonly the central nervous system. Although OEIS complex is well-recognized in the clinical setting, there remains a significant lack of understanding of this condition at both the developmental and the genetic level. While most cases are sporadic, familial cases have been reported, suggesting that one or more specific genes may play a significant role in this condition. Several developmental mechanisms have been proposed to explain the etiology of OEIS complex, and it is generally considered to be a defect early in caudal mesoderm development and ventral body wall closure. The goal of this study was to identify genetic aberrations in 13 patients with OEIS/EC using a combination of candidate gene analysis and microarray studies. Analysis of 14 candidate genes in combination with either high resolution SNP or oligonucleotide microarray did not reveal any disease-causing mutations, although novel variants were identified in five patients. To our knowledge, this is the most comprehensive genetic analysis of patients with OEIS complex to date. We conclude that OEIS is a complex disorder from an etiological perspective, likely involving a combination of genetic and environmental predispositions. Based on our data, OEIS complex is unlikely to be caused by a recurrent chromosomal aberration. © 2010 Wiley-Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | Comprehensive genetic analysis of OEIS complex reveals no evidence for a recurrent microdeletion or duplication | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan ; Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Urology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan, Ann Arbor, Michigan ; 1150 W. Medical Center Dr., 3520C MSRB I, Box 5652, Ann Arbor, MI 48109-5652. | en_US |
dc.contributor.affiliationother | Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Human Genetics, Nijmegen Centre for Molecular Life Sciences, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Pediatrics/Division of Medical Genetics, University of Iowa Hospital & Clinics, Iowa City, Iowa | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83173/1/33757_ftp.pdf | |
dc.identifier.doi | 10.1002/ajmg.a.33757 | en_US |
dc.identifier.source | American Journal of Medical Genetics Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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