HPV types and variants among cervical cancer tumors in three regions of Tunisia
dc.contributor.author | KrennHrubec, Keris | en_US |
dc.contributor.author | Mrad, Karima | en_US |
dc.contributor.author | Sriha, Badreddine | en_US |
dc.contributor.author | Ayed, Farhat Ben | en_US |
dc.contributor.author | Bottalico, Danielle M. | en_US |
dc.contributor.author | Ostolaza, Janae | en_US |
dc.contributor.author | Smith, Benjamin | en_US |
dc.contributor.author | Tchaikovska, Tatyana | en_US |
dc.contributor.author | Soliman, Amr S. | en_US |
dc.contributor.author | Burk, Robert D. | en_US |
dc.date.accessioned | 2011-03-10T16:02:55Z | |
dc.date.accessioned | 2011-03-10T16:02:55Z | |
dc.date.available | 2012-05-14T20:40:08Z | en_US |
dc.date.issued | 2011-04 | en_US |
dc.identifier.citation | KrennHrubec, Keris; Mrad, Karima; Sriha, Badreddine; Ayed, Farhat Ben; Bottalico, Danielle M.; Ostolaza, Janae; Smith, Benjamin; Tchaikovska, Tatyana; Soliman, Amr S.; Burk, Robert D. (2011). "HPV types and variants among cervical cancer tumors in three regions of Tunisia." Journal of Medical Virology 83(4): 651-657. <http://hdl.handle.net/2027.42/83181> | en_US |
dc.identifier.issn | 0146-6615 | en_US |
dc.identifier.issn | 1096-9071 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83181 | |
dc.description.abstract | Cervical cancer is the second most common cancer among Tunisian women, and the incidence rates vary by region. Three Tunisian registries report age-standardized rates of 6.3/10 5 in the central region, 5.4/10 5 in the north, and 2.7/10 5 in the south. High-risk human papillomavirus (HPV) types and their variants differ in carcinogenic potential and geographic distribution. The HPV type and variant distribution could be a factor in the differing rates between regions of Tunisia. Tumor tissue was collected from 142 Tunisian cervical cancer patients. Demographic and reproductive characteristics of the patients were abstracted from cancer registry and hospital records. HPV type and variant analyses were performed using PCR-based Luminex and dot-blot hybridization assays. Eighty-three percent of tumors were infected with at least one HPV type. European variants of HPV16/18 were the most prevalent in tumors from all three regions, with all HPV18 infections and 64% of HPV16 infections being of European lineage. A higher frequency of HPV16 was present in Northern Tunisia (80%) than in Central (68%) or Southern Tunisia (50%) ( P = 0.02). HPV18/45 was significantly more common in adenocarcinomas (50%) than in squamous cell carcinomas (11%) ( P = 0.004). Frequent infection with European HPV variants most likely reflects the history of European migration to Tunisia. In addition to the importance of understanding the variants of HPV in Tunisia, behavioral and cultural attitudes towards screening and age-specific infection rates should be investigated to aid the development of future vaccination and HPV screening programs and policies. J. Med. Virol. 83:651–657, 2011. © 2011 Wiley-Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | HPV types and variants among cervical cancer tumors in three regions of Tunisia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan ; University of Michigan School of Public Health, 1415 Washington Heights, 5626 Henry F. Vaughn Public Health Building (SPH I) Ann Arbor, MI 48109-2029. | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Anatomy and Pathology, Salah Azaiez Cancer Institute, Tunis, Tunisia | en_US |
dc.contributor.affiliationother | Department of Anatomy and Pathology, Farhat Hached Hospital, Sousse, Tunisia | en_US |
dc.contributor.affiliationother | Tunisian Association for Cancer Prevention and Control, Tunis, Tunisia | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York | en_US |
dc.contributor.affiliationother | Departments of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York ; Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York ; Departments of Epidemiology and Population Health, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York ; Departments of Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Yeshiva University, Bronx, New York | en_US |
dc.identifier.pmid | 21328380 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83181/1/22011_ftp.pdf | |
dc.identifier.doi | 10.1002/jmv.22011 | en_US |
dc.identifier.source | Journal of Medical Virology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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