Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants
dc.contributor.author | Ye, Ping | |
dc.contributor.author | Kirschner, Denise E. | |
dc.date.accessioned | 2011-03-30T19:43:59Z | |
dc.date.accessioned | 2011-03-30T19:43:59Z | |
dc.date.available | 2011-03-30T19:43:59Z | en_US |
dc.date.issued | 2002-03-11 | |
dc.identifier.citation | The Journal of Immunology, 2002, 169: 4968 – 4979. <http://hdl.handle.net/2027.42/83366> | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed?term=11994448 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/83366 | |
dc.description.abstract | The human thymus exports newly generated T cells to the periphery. As no markers have been identified for these recent thymic emigrants (RTE), it is presently impossible to measure human thymic output. T cell receptor excision circles (TREC) have been recently used to assess thymic output during both health and disease. Using a mathematical model, we quantify age-dependent changes both in the number of RTE generated per day and in TREC concentration during an 80-year lifespan. Through analyses, we demonstrate that RTE and peripheral T cell division have the same potential to affect TREC concentration at any age in healthy people. T cell death also influences TREC concentration, but to a lesser extent. During aging, our results indicate that thymic involution primarily induces an age-dependent decline in TREC concentrations within both CD4+ and CD8+ T cell populations. We further apply this model for studying TREC concentration during HIV-1 infection. Our analyses reveal that a decrease in thymic output is the major contributor to the decline in TREC concentration within CD4+ T cells, whereas both increased peripheral T cell division and decreased thymic output induce the decline in TREC concentration within CD8+ T cells. Therefore, we suggest that T cell turnover should be examined together with TREC concentration as a measure of RTE. If peripheral T cell division remains relatively unchanged, then TREC concentration indeed reflects thymic output. | en_US |
dc.description.sponsorship | This work was supported by National Institutes of Health Grant HL62119 (to D.E.K.) and Elizabeth Glaser Pediatric AIDS Foundation Student Intern Award (to P.Y.). | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | The American Association of Immunologists | en_US |
dc.title | Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Microbiology and Immunology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11994448 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83366/1/ye-jimmunol-2002.pdf | |
dc.identifier.source | The Journal of Immunology | en_US |
dc.owningcollname | Microbiology and Immunology, Department of |
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