Association between type-three metabotropic glutamate receptor gene ( GRM3 ) variants and symptom presentation in treatment refractory schizophrenia
dc.contributor.author | Bishop, Jeffrey R. | en_US |
dc.contributor.author | Miller, Del D. | en_US |
dc.contributor.author | Ellingrod, Vicki L. | en_US |
dc.contributor.author | Holman, Timothy Dean | en_US |
dc.date.accessioned | 2011-04-07T18:52:09Z | |
dc.date.accessioned | 2011-04-07T18:52:09Z | |
dc.date.available | 2012-02-21T18:47:00Z | en_US |
dc.date.issued | 2011-01 | en_US |
dc.identifier.citation | Bishop, Jeffrey R.; Miller, Del D.; Ellingrod, Vicki L.; Holman, Timothy (2011). "Association between type-three metabotropic glutamate receptor gene ( GRM3 ) variants and symptom presentation in treatment refractory schizophrenia." Human Psychopharmacology: Clinical and Experimental 26(1): 28-34. <http://hdl.handle.net/2027.42/83458> | en_US |
dc.identifier.issn | 0885-6222 | en_US |
dc.identifier.issn | 1099-1077 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83458 | |
dc.description.abstract | Objective Positive associations between polymorphisms in the type-three metabotropic glutamate receptor gene ( GRM3 ) and the pathogenesis of schizophrenia as well as response to antipsychotic treatment have been reported. The objective of this study was to determine whether refractory psychiatric symptoms in antipsychotic non-responders are related to polymorphisms in GRM3 . Methods Ninety-five treatment refractory schizophrenia participants were enrolled. Prior to a medication switch, global psychopathology and negative symptoms were rated. These participants were genotyped for seven markers in GRM3 . Genotype associations with symptoms were assessed. Results Two markers in GRM3 (rs1989796 and rs1476455), were associated with the presence of refractory global symptoms as measured by the Brief Psychiatric Rating Scale (BPRS) Total scores. Participants with an rs1476455_CC genotype had significantly higher BPRS scores than A-carriers (55.1 ± 10.4 vs. 48.3 ± 9.2; F = 7.6, p = 0.0071). Additionally, participants with the rs1989796_CC genotype had significantly higher BPRS scores than T-carriers (50.1 ± 5.7 vs. 55.8 ± 10.5, F = 7.1, p = 0.0091). No evidence for significant associations with negative symptoms was observed. Conclusions Polymorphisms in the GRM3 gene may be associated with refractory global psychosis symptoms but not negative symptoms in persons with schizophrenia. Copyright © 2011 John Wiley & Sons, Ltd. | en_US |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Neuroscience, Neurology and Psychiatry | en_US |
dc.title | Association between type-three metabotropic glutamate receptor gene ( GRM3 ) variants and symptom presentation in treatment refractory schizophrenia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, Michigan ; Department of Psychiatry, University of Michigan College of Medicine, Ann Arbor Michigan | en_US |
dc.contributor.affiliationother | Department of Pharmacy Practice, University of Illinois at Chicago College of Pharmacy, Chicago, Illinois ; The University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, 833 S. Wood St. Rm 164 (M/C 886), Chicago, IL 60612. | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa | en_US |
dc.contributor.affiliationother | Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83458/1/1163_ftp.pdf | |
dc.identifier.doi | 10.1002/hup.1163 | en_US |
dc.identifier.source | Human Psychopharmacology: Clinical and Experimental | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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