Longitudinal measures of lung function in infants with bronchopulmonary dysplasia
dc.contributor.author | Filbrun, Amy G. | en_US |
dc.contributor.author | Popova, Antonia P. | en_US |
dc.contributor.author | Linn, Marisa J. | en_US |
dc.contributor.author | McIntosh, Nancy A. | en_US |
dc.contributor.author | Hershenson, Marc B. | en_US |
dc.date.accessioned | 2011-04-07T18:52:13Z | |
dc.date.accessioned | 2011-04-07T18:52:13Z | |
dc.date.available | 2012-05-14T20:40:08Z | en_US |
dc.date.issued | 2011-04 | en_US |
dc.identifier.citation | Filbrun, Amy G.; Popova, Antonia P.; Linn, Marisa J.; McIntosh, Nancy A.; Hershenson, Marc B. (2011). "Longitudinal measures of lung function in infants with bronchopulmonary dysplasia." Pediatric Pulmonology 46(4): 369-375. <http://hdl.handle.net/2027.42/83461> | en_US |
dc.identifier.issn | 8755-6863 | en_US |
dc.identifier.issn | 1099-0496 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83461 | |
dc.description.abstract | We previously demonstrated that infants with a history of bronchopulmonary dysplasia (BPD) exhibit airflow obstruction and air trapping. The purpose of this study was to assess longitudinal changes in pulmonary function in infants with a history of BPD over the first 3 years of life, and the relationship to somatic growth. Spirometry was measured using the raised volume rapid thoracoabdominal compression technique, and lung volumes measured by plethysmography. Eighteen infants (mean gestational age ± SD 27.3 ± 2.2 weeks, birthweight 971 ± 259 g) underwent two lung function studies. Average age at first test was 58.8 weeks. Spirometry demonstrated significant reductions in forced expiratory volume in 0.5 sec (FEV 0.5 , 76.0 ± 15.9% predicted, Z-score −2.13 ± 1.69), forced expiratory flow at 75% of expired forced vital capacity (FEF 75 , 54.8 ± 31.1%, −3.58 ± 2.73), and FEF 25–75 (67.8 ± 33.3%, −1.79 ± 1.76). Group mean total lung capacity (TLC) was in the low normal range (82.9 ± 13.5% predicted) and residual volume (RV)/TLC was mildly elevated (122.4 ± 38.2% predicted). Repeat testing was performed an average of 32.7 weeks after initial testing. At re-evaluation, group mean lung volumes and flows tracked at or near their previous values; thus, in general, there was a lack of catch-up growth. However, compared to infants with below average or average somatic growth (as represented by g/day), infants with above average growth showed significantly greater improvements in percent predicted FVC, FEV 0.5 , TLC, and RV/TLC (all P < 0.05, ANOVA). We conclude that longitudinal measures of pulmonary function in infants and young children with BPD demonstrate significant airflow obstruction and modest restriction, which tends to persist with time. On the other hand, infants with above average somatic growth showed greater lung growth than their peers. Additional studies examining the effects of various nutritional regimens on lung function are warranted. Pediatr Pulmonol. 2011; 46:369–375. © 2010 Wiley-Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Miscellaneous Medical | en_US |
dc.title | Longitudinal measures of lung function in infants with bronchopulmonary dysplasia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan ; Department of Pediatrics and Communicable Diseases, University of Michigan, 1500 East Medical Center Drive, L2221 Women's Hospital, Box 0212, Ann Arbor 48109-0212, MI. | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan | en_US |
dc.identifier.pmid | 21438170 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83461/1/21378_ftp.pdf | |
dc.identifier.doi | 10.1002/ppul.21378 | en_US |
dc.identifier.source | Pediatric Pulmonology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.