Model of HIV-1 Disease Progression Based on Virus-Induced Lymph Node Homing and Homing-Induced Apoptosis of CD4+ Lymphocytes
dc.contributor.author | Kirschner, Denise E. | |
dc.contributor.author | Webb, Glenn F. | |
dc.contributor.author | Cloyd, Miles | |
dc.date.accessioned | 2011-04-13T15:30:57Z | |
dc.date.accessioned | 2011-04-13T15:30:57Z | |
dc.date.available | 2011-04-13T15:30:57Z | en_US |
dc.date.issued | 2000-08-01 | |
dc.identifier.citation | JAIDS, vol. 24, no. 4, 2000, pp. 352–362 <http://hdl.handle.net/2027.42/83499> | en_US |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/pubmed?term=11015152 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/83499 | |
dc.description.abstract | Several proposed theories have described the progression of HIV infection. Even so, no concrete evidence supports any as comprehensive, including, for example, why the CD4+ T-cell counts fall from 1000/mm^3 of blood to roughly 100/mm^3 over an average 10-year period, whereas concomitant viral loads are relatively constant, increasing by several orders of magnitude in late-stage disease. Here, we develop and validate a theoretical model that altered lymphocyte circulation patterns between the lymph system and blood due to HIV-induced enhanced lymph-node homing and subsequent apoptosis of resting CD4+ T cells can explain many aspects of HIV-1 disease progression. These results lead to a recalculation of the CD4+ lymphocyte dynamics during highly active antiretroviral therapy, and also suggest new targets for therapy. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Lippincott Williams & Wilkins, Inc., Philadelphia | en_US |
dc.subject | HIV | en_US |
dc.subject | Lymphocytes | en_US |
dc.subject | Homing | en_US |
dc.subject | Apoptosis | en_US |
dc.subject | Mathematical Model | en_US |
dc.title | Model of HIV-1 Disease Progression Based on Virus-Induced Lymph Node Homing and Homing-Induced Apoptosis of CD4+ Lymphocytes | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Microbiology and Immunology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 11015152 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83499/1/Kirschner_et_al.jaids2000.pdf | |
dc.identifier.source | Journal of Acquired Immune Deficiency Syndromes | en_US |
dc.owningcollname | Microbiology and Immunology, Department of |
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