Revisiting Early Models of the host-pathogen interactions in HIV infection
dc.contributor.author | Covert, D. | |
dc.contributor.author | Kirschner, Denise E. | |
dc.date.accessioned | 2011-04-21T12:50:03Z | |
dc.date.available | 2011-04-21T12:50:03Z | |
dc.date.issued | 2000 | |
dc.identifier.citation | Comments on Theoretical Biology, 5:383-411, 2000 <http://hdl.handle.net/2027.42/83541> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83541 | |
dc.description.abstract | The interactions between infectious pathogens and the immune system have been mathematically modeled for numerous diseases. Human immunodeficiency virus (HIV), the agent that causes AIDS, has been modeled most extensively. In 1986, three years after HIV was isolated, investigators produced the first mathematical description of its pathogenesis. Since that time modelers have steadily developed more sophisticated systems that have brought the field of mathematical modeling to the consciousness of virologists and immunologists. In this paper we review five of the first attempts of modeling HIV and the immune system. We consider these models in their own right as predictors for CD4+ T-cell depletion and viral growth, as records of the immunovirological understanding of the day, and as forerunners of the current generation of models. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Overseas Publishers Association | en_US |
dc.subject | Mathematical Modeling | en_US |
dc.subject | HIV | en_US |
dc.subject | Human Immune System | en_US |
dc.subject | Numerical Simulations | en_US |
dc.title | Revisiting Early Models of the host-pathogen interactions in HIV infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Microbiology and Immunology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83541/1/Covert-Kirschner-2000.pdf | |
dc.identifier.source | Comments on Theoretical Biology | en_US |
dc.owningcollname | Microbiology and Immunology, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.