Immunotherapy of HIV-1 Infection
dc.contributor.author | Kirschner, Denise E. | |
dc.contributor.author | Webb, Glenn F. | |
dc.date.accessioned | 2011-04-28T20:21:41Z | |
dc.date.available | 2011-04-28T20:21:41Z | |
dc.date.issued | 1998 | |
dc.identifier.citation | Journal of Biological Systems, Vol. 6, No. 1 (1998) 71-83 <http://hdl.handle.net/2027.42/83697> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83697 | |
dc.description.abstract | A number of lines of evidence suggest that immunotherapy with the cytokine interleukin-2 (IL-2) may boost the immune response to fight HIV infection. CD4+ T cells, the cells which orchestrate the immune response, are also the cells that become infected by the HIV virus. These cells use cytokines as signaling mechanisms for immune-response stimulation, growth, and differentiation. Since CD4+ T cells are hampered due to HIV infection, normal signaling, and the resulting cascade, may not occur. Introduction of IL-2 into the system can restore or enhance these effects. We illustrate, through mathematical modeling, the effects of IL-2 treatment on an HIV-infected patient. With good comparison to existing clinical data, we can better understand what mechanisms of immune-viral dynamics are necessary to produce the typical disease dynamics. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | World Scientific Publishing Company | en_US |
dc.subject | HIV | en_US |
dc.subject | CD4+ T Cells | en_US |
dc.subject | Turnover Rates | en_US |
dc.subject | Production Rates | en_US |
dc.subject | Interleukin | en_US |
dc.subject | Immunotherapy | en_US |
dc.subject | Mathematical Model | en_US |
dc.subject | Ordinary Differential Equations (ODEs) | en_US |
dc.subject | Lymph System | en_US |
dc.title | Immunotherapy of HIV-1 Infection | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Microbiology and Immunology | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Microbiology and Immunology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83697/1/Kirschner-JBS-1998.pdf | |
dc.identifier.source | Journal of Biological Systems | en_US |
dc.owningcollname | Microbiology and Immunology, Department of |
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