Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability
dc.contributor.author | Chandrakasan, Shanmuganathan | en_US |
dc.contributor.author | Ye, Christine J. | en_US |
dc.contributor.author | Chitlur, Meera B. | en_US |
dc.contributor.author | Mohamed, Anwar N. | en_US |
dc.contributor.author | Rabah, Raja M. | en_US |
dc.contributor.author | Konski, Andre | en_US |
dc.contributor.author | Heng, Henry H. Q. | en_US |
dc.contributor.author | Sava≽an, Süreyya | en_US |
dc.date.accessioned | 2011-05-06T15:39:08Z | |
dc.date.available | 2012-09-04T15:27:09Z | en_US |
dc.date.issued | 2011-07-01 | en_US |
dc.identifier.citation | Chandrakasan, Shanmuganathan; Ye, Christine J.; Chitlur, Meera; Mohamed, Anwar N.; Rabah, Raja; Konski, Andre; Heng, Henry H. Q.; Sava≽an, Süreyya (2011). "Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability." Pediatric Blood & Cancer 56(7): 1143-1145. <http://hdl.handle.net/2027.42/83748> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/83748 | |
dc.description.abstract | Secondary malignancies (SMs) in Hodgkin lymphoma (HL) are thought to be related to exposure to alkalating agents, topoisomerase II inhibitors and ionizing radiation, and tend to occur a decade after initial therapy. We report a 14 year old autistic male, who developed malignant fibrous histiocytoma (MFH) two years after autologous stem cell transplantation for advanced stage HL. The MFH and post-surgical reactive tissues exhibited multiple clonal abnormalities. In addition, PHA-stimulated peripheral blood lymphocytes showed increased frequency of non-clonal chromosomal aberrations. The potential role of genomic instability in early onset of SM in our patient is discussed. Pediatr Blood Cancer 2011;56:1143–1145. © 2010 Wiley-Liss, Inc. | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Malignant fibrous histiocytoma two years after autologous stem cell transplant for Hodgkin lymphoma: Evidence for genomic instability | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Division of Pediatric Hematology Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Center for Molecular Medicine and Genetics, Barbara Ann Karmanos Cancer Center, Wayne State University, Michigan | en_US |
dc.contributor.affiliationother | Division of Pediatric Hematology Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Department of Pathology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Department of Pathology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, Barbara Ann Karmanos Cancer Center, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Center for Molecular Medicine and Genetics, Barbara Ann Karmanos Cancer Center, Wayne State University, Michigan | en_US |
dc.contributor.affiliationother | Division of Pediatric Hematology Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan ; Pediatric Blood and Marrow Transplantation, Barbara Ann Karmanos Cancer Center, Wayne State University, Detroit, Michigan ; 3901 Beaubien Blvd., Children's Hospital of Michigan, Division of Hematology/Oncology, Pediatric Blood and Marrow Transplantation, Detroit, Michigan 48201. | en_US |
dc.identifier.pmid | 21488163 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/83748/1/22929_ftp.pdf | |
dc.identifier.doi | 10.1002/pbc.22929 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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