In Vivo Characterization of Pancreatic and Lymph Node Tissue using Endoscopic Ultrasound Spectrum Analysis: Validation Study
dc.contributor.author | Kumon, Ronald E. | |
dc.contributor.author | Pollack, Michael J. | |
dc.contributor.author | Faulx, Ashley L. | |
dc.contributor.author | Olowe, Kayode | |
dc.contributor.author | Farooq, Farees T. | |
dc.contributor.author | Chen, Victor K. | |
dc.contributor.author | Zhou, Yun | |
dc.contributor.author | Wong, Richard C. K. | |
dc.contributor.author | Isenberg, Gerard A. | |
dc.contributor.author | Sivak, Michael V. | |
dc.contributor.author | Chak, Amitabh | |
dc.contributor.author | Deng, Cheri X. | |
dc.date.accessioned | 2011-06-01T17:00:58Z | |
dc.date.available | 2011-06-01T17:00:58Z | |
dc.date.issued | 2010-01 | |
dc.identifier.citation | Gastrointestinal Endoscopy, vol. 71, no. 1, 2010, pp. 53-63 <http://hdl.handle.net/2027.42/84357> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/84357 | |
dc.description | Published on PubMed Central on 01 January 2011 | en_US |
dc.description.abstract | Background—Quantitative spectral analysis of the radio-frequency (RF) signals that underlie grayscale EUS images can be used to provide additional, objective information about tissue state. Objective—Our purpose was to validate RF spectral analysis as a method to distinguish between (1) benign and malignant lymph nodes and (2) normal pancreas (NP), chronic pancreatitis (CP) and pancreatic cancer (PC). Design & Setting—A prospective validation study of eligible patients was conducted to compare with pilot study RF data. Patients—Forty-three patients underwent EUS of the esophagus, stomach, pancreas, and surrounding intra-abdominal and mediastinal lymph nodes (19 from previous pilot study and 24 additional patients). Main Outcome Measurements—Midband fit, slope, intercept, and correlation coefficient from a linear regression of the calibrated RF power spectra were determined. Results—Discriminant analysis of mean pilot-study parameters was then performed to classify validation-study parameters. For benign vs. malignant lymph nodes, midband-fit and intercept (both with t-test p < 0.058) provided classification with 67% accuracy and area under ROC curve (AUC) of 0.86. For diseased vs. NP, midband-fit and correlation coefficient (both with ANOVA p < 0.001) provided 93% accuracy and AUC of 0.98. For PC vs. CP, the same parameters provided 77% accuracy and AUC of 0.89. Results improved further when classification was performed with all data. Limitations—Moderate sample size and spatial averaging inherent to the technique. Conclusions—This study confirms that mean spectral parameters provide a non-invasive method to quantitatively discriminate benign and malignant lymph nodes as well as normal and diseased pancreas. | en_US |
dc.description.sponsorship | Ohio Wright Center of Innovation/Biomedical Research and Technology Transfer Grant “Biomedical structural, functional and molecular imaging enterprise.” | en_US |
dc.description.sponsorship | K24 Midcareer Award in Patient Oriented Research, National Institutes of Health (Grant DK002800) to Amitabh Chak | en_US |
dc.description.sponsorship | American Society for Gastrointestinal Endoscopy Research, Outcomes, and Effectiveness Award | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Endoscopic Ultrasound | en_US |
dc.subject | Spectrum Analysis | en_US |
dc.subject | Ultrasound Backscatter | en_US |
dc.subject | Pancreatic Adenocarcinoma | en_US |
dc.subject | Chronic Pancreatitis | en_US |
dc.subject | Lymph Nodes | en_US |
dc.subject | Linear Discriminant Analysis | en_US |
dc.subject | Receiver-operating Characteristic Curve | en_US |
dc.subject | Computer Aided Diagnosis | en_US |
dc.subject | Cancer | en_US |
dc.title | In Vivo Characterization of Pancreatic and Lymph Node Tissue using Endoscopic Ultrasound Spectrum Analysis: Validation Study | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | |
dc.subject.hlbtoplevel | Engineering | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biomedical Engineering, Department of | en_US |
dc.contributor.affiliationother | Division of Gastroenterology, University Hospitals Case Medical Center and Case Western Reserve University | en_US |
dc.contributor.affiliationother | Division of Gastroenterology and Hepatology, University of Texas Health Science Center | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/84357/1/nihms147644.pdf | |
dc.identifier.doi | 10.1016/j.gie.2009.08.027 | |
dc.identifier.source | Gastrointestinal Endoscopy | en_US |
dc.owningcollname | Biomedical Engineering, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.