Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model
dc.contributor.author | Kumon, Ronald E. | |
dc.contributor.author | Deng, Cheri X. | |
dc.contributor.author | Wang, Xueding | |
dc.date.accessioned | 2011-06-01T17:24:43Z | |
dc.date.available | 2011-06-01T17:24:43Z | |
dc.date.issued | 2011-05 | |
dc.identifier.citation | Ultrasound in Medicine and Biology, vol. 37, no. 5, 2011, pp. 834-839 <http://hdl.handle.net/2027.42/84362> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/84362 | |
dc.description | Accepted Author Manuscript | en_US |
dc.description.abstract | Photoacoustic imaging is an emerging technique for anatomical and functional sub-surface imaging, but previous studies have predominantly focused on time-domain analysis. In this study, frequency-domain analysis of the radio-frequency signals from photoacoustic imaging was performed to generate quantitative parameters for tissue characterization. To account for the response of the imaging system, the photoacoustic spectra were calibrated by dividing the photoacoustic spectra (radio-frequency ultrasound spectra resulting from laser excitation) from tissue by the photoacoustic spectrum of a point absorber excited under the same conditions. The resulting quasi-linear photoacoustic spectra were fit by linear regression, and midband fit, slope, and intercept were computed from the best-fit line. These photoacoustic spectral parameters were compared between the region-of-interests (ROIs) representing prostate adenocarcinoma tumors and adjacent normal flank tissue in a murine model. The mean midband fit and intercept in the ROIs showed significant differences between cancerous and non-cancerous regions. These initial results suggest that such frequency-domain analysis can provide a quantitative method for tumor tissue characterization using photoacoustic imaging in vivo. | en_US |
dc.description.sponsorship | National Institutes of Health grant R01AR055179 | en_US |
dc.description.sponsorship | University of Michigan | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Photoacoustic Imaging | en_US |
dc.subject | Medical and Biological Imaging | en_US |
dc.subject | Imaging Systems | en_US |
dc.subject | Frequency Domain | en_US |
dc.subject | Spectrum Analysis | en_US |
dc.subject | Tissue Characterization | en_US |
dc.subject | Prostate Cancer | en_US |
dc.title | Frequency-domain analysis of photoacoustic imaging data from prostate adenocarcinoma tumors in a murine model | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | |
dc.subject.hlbtoplevel | Engineering | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biomedical Engineering, Department of | en_US |
dc.contributor.affiliationum | Radiology, Deparment of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/84362/1/KumonRE-UMB-2011-AcceptedAuthorManuscript.pdf | |
dc.identifier.doi | 10.1016/j.ultrasmedbio.2011.01.012 | |
dc.identifier.source | Ultrasound in Medicine and Biology | en_US |
dc.description.mapping | -1 | en_US |
dc.owningcollname | Biomedical Engineering, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.