A Preliminary Investigation of Neural Correlates of Treatment in Adolescents with Generalized Anxiety Disorder
dc.contributor.author | Maslowsky, Julie | en_US |
dc.contributor.author | Mogg, Karin | en_US |
dc.contributor.author | Bradley, Brendan P. | en_US |
dc.contributor.author | McClure-Tone, Erin | en_US |
dc.contributor.author | Ernst, Monique | en_US |
dc.contributor.author | Pine, Daniel S. | en_US |
dc.contributor.author | Monk, Christopher S. | en_US |
dc.date.accessioned | 2011-06-17T20:26:44Z | |
dc.date.available | 2011-06-17T20:26:44Z | |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Maslowsky, Julie; Mogg, Karin; Bradley, Brendan P.; McClure-Tone, Erin; Ernst, Monique; Pine, Daniel S.; Monk, Christopher S. (2010/04/01). "A Preliminary Investigation of Neural Correlates of Treatment in Adolescents with Generalized Anxiety Disorder." Journal of Child and Adolescent Psychopharmacology, 20(2): 105-111 <http://hdl.handle.net/2027.42/85098> | en_US |
dc.identifier.issn | 1044-5463 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/85098 | |
dc.description.abstract | Abstract Objective: Generalized anxiety disorder (GAD) is a prevalent and debilitating psychiatric condition of adolescence. Two effective forms of treatment are cognitive behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). This pilot study examined changes in brain function following each type of treatment in GAD. Method: Subjects were 14 youths with GAD (7 had CBT, 7 received fluoxetine) and 10 age- and gender-matched healthy peers. Functional magnetic resonance imaging (fMRI) scans were acquired before and after treatment for patients and over two comparable time points for controls. During fMRI acquisition, a probe detection task with emotional (angry, happy) and neutral faces allowed for assessment of neural response to threat. Following previous research, region of interest analyses were performed in the right ventrolateral prefrontal cortex (VLPFC). Results: fMRI results showed increased right VLPFC activation, relative to controls, in the medication (t(15)?=?3.01, p?<?0.01) and CBT (t(15)?=?3.22, p?<?0.01) groups following treatment. Conclusions: This study shows significant increase in right VLPFC activation in response to angry faces following treatment with CBT or fluoxetine for GAD. This is consistent with previous research indicating that the VLPFC may facilitate effective responding to underlying neural correlates of anxiety in other brain regions, such as the amygdala. | en_US |
dc.publisher | Mary Ann Liebert, Inc., publishers | en_US |
dc.title | A Preliminary Investigation of Neural Correlates of Treatment in Adolescents with Generalized Anxiety Disorder | en_US |
dc.type | Article | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.identifier.pmid | 20415605 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/85098/1/cap_2009_0049.pdf | |
dc.identifier.doi | 10.1089/cap.2009.0049 | en_US |
dc.identifier.source | Journal of Child and Adolescent Psychopharmacology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.