Show simple item record

Treatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174

dc.contributor.authorSmith, Kimberlyen_US
dc.contributor.authorZheng, Luen_US
dc.contributor.authorBosch, Ronalden_US
dc.contributor.authorMargolis, David M.en_US
dc.contributor.authorTenorio, Allanen_US
dc.contributor.authorNapolitano, Lauraen_US
dc.contributor.authorSaag, Michaelen_US
dc.contributor.authorConnick, Elizabethen_US
dc.contributor.authorGross, Barryen_US
dc.contributor.authorFrancis, Isaac R.en_US
dc.contributor.authorValdez, Hernanen_US
dc.contributor.authorMuurahainen, Normaen_US
dc.contributor.authorStocker, Vickyen_US
dc.contributor.authorPollard, Richarden_US
dc.date.accessioned2011-06-17T20:27:29Z
dc.date.available2011-06-17T20:27:29Z
dc.date.issued2010en_US
dc.identifier.citationSmith, Kimberly; Zheng, Lu; Bosch, Ronald; Margolis, David M.; Tenorio, Allan; Napolitano, Laura; Saag, Michael; Connick, Elizabeth; Gross, Barry; Francis, Isaac; Valdez, Hernan; Muurahainen, Norma; Stocker, Vicky; Pollard, Richard (2010/04/01). "Treatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174." AIDS Research and Human Retroviruses, 26(4): 425-432 <http://hdl.handle.net/2027.42/85134>en_US
dc.identifier.issn0889-2229en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/85134
dc.description.abstractAbstract Pilot studies have suggested that treatment with recombinant human growth hormone (rhGH) is associated with increased T-lymphocyte restoration and enhanced thymic output. We evaluated the immunologic effects of rhGH on HIV+ subjects with incomplete immune reconstitution on antiretroviral therapy (ART). Sixty subjects were randomized to receive rhGH 1.5?mg scqd and ART for 48 weeks (Arm A) or continue ART alone for 24 weeks then add rhGH 3.0?mg scqd for 24 weeks (Arm B). Median baseline CD4 for Arms A and B were 223 and 219, respectively. There was little difference between Arm A and Arm B in change in total or naive CD4 cells or percentage from baseline to week 24. Only one subject in Arm A met the primary endpoint, an increase in naive CD4 percentage of at least 10 percentage points. By week 48 both Arms had statistically significant increases in naive CD4 cell count and percentage and thymus size. Within Arm B, treatment with rhGH was associated with significant increases in naive CD4+ cell count and percentage compared with ART alone. Treatment with rhGH +ART may be associated with modest increases in CD4 lymphocytes over ART alone in subjects with CD4 <350, yet the origin of these naive cells and their impact on immune function require further investigationen_US
dc.publisherMary Ann Liebert, Inc., publishersen_US
dc.titleTreatment with Recombinant Growth Hormone Is Associated with Modest Improvement in CD4 Lymphocyte Reconstitution in HIV-Infected Persons on Antiretroviral Therapy: Results of ACTG A5174en_US
dc.typeArticleen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.identifier.pmid20415638en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/85134/1/aid_2009_0052.pdf
dc.identifier.doi10.1089/aid.2009.0052en_US
dc.identifier.sourceAIDS Research and Human Retrovirusesen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


Files in this item

Show simple item record

Remediation of Harmful Language

The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.

Accessibility

If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.