Cell and biomolecule delivery for regenerative medicine
dc.contributor.author | Smith, Ian O. | en_US |
dc.contributor.author | Ma, Peter X. | en_US |
dc.date.accessioned | 2011-08-10T13:53:37Z | |
dc.date.available | 2011-08-10T13:53:37Z | |
dc.date.issued | 2010-02 | en_US |
dc.identifier.citation | Smith, Ian O.; Ma, Peter X. (2010). "Cell and biomolecule delivery for regenerative medicine." Science and Technology of Advanced Materials, 11(1): 014102. <http://hdl.handle.net/2027.42/85429> | en_US |
dc.identifier.issn | 1468-6996 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/85429 | |
dc.description.abstract | Regenerative medicine is an exciting field that aims to create regenerative alternatives to harvest tissues for transplantation. In this approach, the delivery of cells and biological molecules plays a central role. The scaffold (synthetic temporary extracellular matrix) delivers cells to the regenerative site and provides three-dimensional environments for the cells. To fulfil these functions, we design biodegradable polymer scaffolds with structural features on multiple size scales. To enhance positive cell–material interactions, we design nano-sized structural features in the scaffolds to mimic the natural extracellular matrix. We also integrate micro-sized pore networks to facilitate mass transport and neo tissue regeneration. We also design novel polymer devices and self-assembled nanospheres for biomolecule delivery to recapitulate key events in developmental and wound healing processes. Herein, we present recent work in biomedical polymer synthesis, novel processing techniques, surface engineering and biologic delivery. Examples of enhanced cellular/tissue function and regenerative outcomes of these approaches are discussed to demonstrate the excitement of the biomimetic scaffold design and biologic delivery in regenerative medicine. | en_US |
dc.title | Cell and biomolecule delivery for regenerative medicine | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/85429/1/stam10_1_014102.pdf | |
dc.identifier.doi | 10.1088/1468-6996/11/1/014102 | en_US |
dc.identifier.source | Science and Technology of Advanced Materials | en_US |
dc.owningcollname | Physics, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.