Fast joint reconstruction of dynamic $R_2^*$ and field maps in functional MRI.
dc.contributor.author | Olafsson, Valur Thor | en_US |
dc.contributor.author | Noll, Douglas C. | en_US |
dc.contributor.author | Fessler, Jeffrey A. | en_US |
dc.date.accessioned | 2011-08-18T18:21:20Z | |
dc.date.available | 2011-08-18T18:21:20Z | |
dc.date.issued | 2008-02-02 | en_US |
dc.identifier.citation | Olafsson, V.T.; Noll, D.C.; Fessler, J.A. (2008). "Fast Joint Reconstruction of Dynamic $R_2^*$ and Field Maps in Functional MRI." IEEE Transactions on Medical Imaging 27(9): 1177-1188. <http://hdl.handle.net/2027.42/86002> | en_US |
dc.identifier.issn | 0278-0062 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/86002 | |
dc.description.abstract | Blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) is conventionally done by reconstructing T2 * -weighted images. However, since the images are unitless they are nonquantifiable in terms of important physiological parameters. An alternative approach is to reconstruct R2 * maps which are quantifiable and have comparable BOLD contrast as T2* -weighted images. However, conventional R2 * mapping involves long readouts and ignores relaxation during readout. Another problem with fMRI imaging is temporal drift/fluctuations in off-resonance. Conventionally, a field map is collected at the start of the fMRI study to correct for off-resonance, ignoring any temporal changes. Here, we propose a new fast regularized iterative algorithm that jointly reconstructs R2 * and field maps for all time frames in fMRI data. To accelerate the algorithm we linearize the MR signal model, enabling the use of fast regularized iterative reconstruction methods. The regularizer was designed to account for the different resolution properties of both R2 * and field maps and provide uniform spatial resolution. For fMRI data with the same temporal frame rate as data collected for T2 * -weighted imaging the resulting R2 * maps performed comparably to T2 * -weighted images in activation detection while also correcting for spatially global and local temporal changes in off-resonance. | en_US |
dc.publisher | IEEE | en_US |
dc.title | Fast joint reconstruction of dynamic $R_2^*$ and field maps in functional MRI. | en_US |
dc.type | article | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Electrical Engineering and Computer Science. Biomedical Engineering Department. | en_US |
dc.identifier.pmid | 18753040 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/86002/1/Fessler23.pdf | |
dc.identifier.doi | 10.1109/TMI.2008.917247 | en_US |
dc.identifier.source | IEEE Transactions on Medical Imaging | en_US |
dc.owningcollname | Electrical Engineering and Computer Science, Department of (EECS) |
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