Now showing items 1-10 of 19
Increased prostacyclin and adverse hemodynamic responses to protamine sulfate in an experimental canine model
(Elsevier, 1991-05)
Prostanoid activity was correlated with the hemodynamic effects of protamine sulfate reversal of heparin in 24 dogs undergoing three different pretreatment regimens: Group I (n = 8) received saline, Group II (n = 8) received ...
Predictors of postoperative outcome after general surgical procedures in patients with congenital heart disease
(Elsevier, 1994-07)
This study was undertaken to evaluate factors predictive of postoperative outcome after general surgical (GS) procedures in patients with congenital heart disease (CHD). All patients with a diagnosis of CHD who underwent ...
Absence of complement-mediated events after protamine reversal of heparin anticoagulation
(Elsevier, 1991-07)
Protamine reversal of heparin anticoagulation is associated with adverse hemodynamic effects that may be attenuated with protamine pretreatment (PP). This study assesses the role of complement activation during these ...
Precursor Trapping: A "Neonatal" Mechanism of Myocardial Protection
(Elsevier, 1993-06)
During induced ischemia for cardiac surgery, 5'-nucleotidase (5NT) catalyzes nucleotide breakdown by dephosphorylating AMP and IMP to diffusible precursors--adenosine and inosine. These precursors become unavailable upon ...
Reversal of Low-Molecular-Weight Heparin Anticoagulation by Synthetic Protamine Analogues
(Elsevier, 1994-06)
Protamine reversal of unfractionated and low-molecular-weight heparin (LMWH) causes hypotension, bradycardia, pulmonary artery hypertension, and declines in oxygen consumption. Furthermore, protamine incompletely reverses ...
The incidence of bilateral well-differentiated thyroid cancer found at completion thyroidectomy
(Springer-Verlag; Société Internationale de Chirurgie, 1992-07)
The purpose of this study was to evaluate the surgical outcome of completion thyroidectomy in patients with presumed unilateral well-differentiated thyroid cancer (WDTC). The medical records of all patients having had ...
Pretreatment with sedative-hypnotics, but not with nondepolarizing muscle relaxants, attenuates alfentanil-induced muscle rigidity
(Elsevier, 1994)
Study Objective: To evaluate and compare the efficacy of various pretreatment agents to attenuate or prevent opioid-induced muscle rigidity using a well-established, previously described clinical protocol.Design: Prospective, ...
The Effect of Combination Cyclosporine and CTLA4-Ig Therapy on Cardiac Allograft Survival
(Elsevier, 1994-07)
Transplant rejection requires not only T cell receptor/CD3 complex activation by foreign MHC, but also additional costimulatory signals, as T cell receptor activation alone is insufficient for induction of the immune ...
Amino acid substrate preloading and postischemic myocardial recovery
(Elsevier, 1992-10)
During induced myocardial ischemia for cardiac surgery, myocardial stunning occurs and aerobic metabolism of glucose, fatty acids, and lactate is inhibited as anaerobic pathways predominate. Even following reperfusion, ...
ATP precursor depletion and postischemic myocardial recovery
(Elsevier, 1991-06)
Although cardioplegia reduces myocardial metabolism during ischemia, adenosine triphosphate (ATP) depletion occurs, which may contribute to poor functional recovery after reperfusion. Augmenting myocardial adenosine during ...