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Methods of investigation for cardiac autonomic dysfunction in human research studies
dc.contributor.authorBernardi, Lucianoen_US
dc.contributor.authorSpallone, Vincenzaen_US
dc.contributor.authorStevens, Martin J.en_US
dc.contributor.authorHilsted, Janniken_US
dc.contributor.authorFrontoni, Simonaen_US
dc.contributor.authorPop‐busui, Rodicaen_US
dc.contributor.authorZiegler, Danen_US
dc.contributor.authorKempler, Peteren_US
dc.contributor.authorFreeman, Royen_US
dc.contributor.authorLow, Phillip A.en_US
dc.contributor.authorTesfaye, Solomonen_US
dc.contributor.authorValensi, Paulen_US
dc.date.accessioned2011-11-10T15:33:51Z
dc.date.available2012-12-03T21:17:29Zen_US
dc.date.issued2011-10en_US
dc.identifier.citationBernardi, Luciano; Spallone, Vincenza; Stevens, Martin; Hilsted, Jannik; Frontoni, Simona; Pop‐busui, Rodica ; Ziegler, Dan; Kempler, Peter; Freeman, Roy; Low, Phillip; Tesfaye, Solomon; Valensi, Paul (2011). "Methods of investigation for cardiac autonomic dysfunction in human research studies." Diabetes/Metabolism Research and Reviews 27(7): 654-664. <http://hdl.handle.net/2027.42/86917>en_US
dc.identifier.issn1520-7552en_US
dc.identifier.issn1520-7560en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/86917
dc.description.abstractThis consensus document provides evidence‐based guidelines regarding the evaluation of diabetic cardiovascular autonomic neuropathy (CAN) for human research studies; the guidelines are the result of the work of the CAN Subcommittee of the Toronto Diabetic Neuropathy Expert Group. The subcommittee critically reviewed the limitations and strengths of the available diagnostic approaches for CAN and the need for developing new tests for autonomic function. It was concluded that the most sensitive and specific approaches currently available to evaluate CAN in clinical research are: (1) heart rate variability, (2) baroreflex sensitivity, (3) muscle sympathetic nerve activity, (4) plasma catecholamines, and (5) heart sympathetic imaging. It was also recommended that efforts should be undertaken to develop new non‐invasive and safe CAN tests to be used in clinical research, with higher sensitivity and specificity, for studying the pathophysiology of CAN and evaluating new therapeutic approaches. Copyright © 2011 John Wiley & Sons, Ltd.en_US
dc.publisherJohn Wiley & Sons, Ltd.en_US
dc.subject.otherDiabetic Neuropathyen_US
dc.subject.otherHeart Rate Variabilityen_US
dc.subject.otherBaroreflex Sensitivityen_US
dc.subject.otherMicroneurographyen_US
dc.subject.otherCatecholaminesen_US
dc.subject.otherCardiac Imagingen_US
dc.titleMethods of investigation for cardiac autonomic dysfunction in human research studiesen_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelInternal Medicine and Specialtiesen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Internal Medicine, University of Michigan, Ann Arbor, MI, USAen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, IRCCS S.Matteo and University of Pavia, Pavia, Italyen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, University of Tor Vergata, Rome, Italyen_US
dc.contributor.affiliationotherDepartment of Medicine, University of Birmingham, Birmingham, UKen_US
dc.contributor.affiliationotherCopenhagen University Hospital, Copenhagen, Denmarken_US
dc.contributor.affiliationotherInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research, Heinrich Heine University, Düsseldorf, Germanyen_US
dc.contributor.affiliationotherDepartment of Medicine, Semmelweis University, Budapest, Hungaryen_US
dc.contributor.affiliationotherBeth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, MN, USAen_US
dc.contributor.affiliationotherDiabetes Research Unit, Sheffield Teaching Hospitals, Sheffield, UKen_US
dc.contributor.affiliationotherService d'Endocrinologie‐Diabétologie‐Nutrition, Hôpital Jean Verdier, AP‐HP, Université Paris Nord, CRNH‐IdF, Bondy, Franceen_US
dc.contributor.affiliationotherDepartment of Internal Medicine, IRCCS S. Matteo and University of Pavia, Pavia, Italy.en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/86917/1/1224_ftp.pdf
dc.identifier.doi10.1002/dmrr.1224en_US
dc.identifier.sourceDiabetes/Metabolism Research and Reviewsen_US
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dc.owningcollnameInterdisciplinary and Peer-Reviewed


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