Incidence of dementia and cognitive impairment, not dementia in the united states
dc.contributor.author | Plassman, Brenda L. | en_US |
dc.contributor.author | Langa, Kenneth M. | en_US |
dc.contributor.author | McCammon, Ryan J. | en_US |
dc.contributor.author | Fisher, Gwenith G. | en_US |
dc.contributor.author | Potter, Guy G. | en_US |
dc.contributor.author | Burke, James R. | en_US |
dc.contributor.author | Steffens, David C. | en_US |
dc.contributor.author | Foster, Norman L. | en_US |
dc.contributor.author | Giordani, Bruno | en_US |
dc.contributor.author | Unverzagt, Frederick W. | en_US |
dc.contributor.author | Welsh‐bohmer, Kathleen A. | en_US |
dc.contributor.author | Heeringa, Steven G. | en_US |
dc.contributor.author | Weir, David R. | en_US |
dc.contributor.author | Wallace, Robert B. | en_US |
dc.date.accessioned | 2011-11-10T15:34:24Z | |
dc.date.available | 2012-11-02T18:56:40Z | en_US |
dc.date.issued | 2011-09 | en_US |
dc.identifier.citation | Plassman, Brenda L.; Langa, Kenneth M.; McCammon, Ryan J.; Fisher, Gwenith G.; Potter, Guy G.; Burke, James R.; Steffens, David C.; Foster, Norman L.; Giordani, Bruno; Unverzagt, Frederick W.; Welsh‐bohmer, Kathleen A. ; Heeringa, Steven G.; Weir, David R.; Wallace, Robert B. (2011). "Incidence of dementia and cognitive impairment, not dementia in the united states." Annals of Neurology 70(3): 418-426. <http://hdl.handle.net/2027.42/86941> | en_US |
dc.identifier.issn | 0364-5134 | en_US |
dc.identifier.issn | 1531-8249 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/86941 | |
dc.description.abstract | Objective: Estimates of incident dementia, and cognitive impairment, not dementia (CIND) (or the related mild cognitive impairment) are important for public health and clinical care policy. In this paper, we report US national incidence rates for dementia and CIND. Methods: Participants in the Aging, Demographic, and Memory Study (ADAMS) were evaluated for cognitive impairment using a comprehensive in‐home assessment. A total of 456 individuals aged 72 years and older, who were not demented at baseline, were followed longitudinally from August 2001 to December 2009. An expert consensus panel assigned a diagnosis of normal cognition, CIND, or dementia and its subtypes. Using a population‐weighted sample, we estimated the incidence of dementia, Alzheimer disease (AD), vascular dementia (VaD), and CIND by age. We also estimated the incidence of progression from CIND to dementia. Results: The incidence of dementia was 33.3 (standard error [SE], 4.2) per 1,000 person‐years and 22.9 (SE, 2.9) per 1,000 person‐years for AD. The incidence of CIND was 60.4 (SE, 7.2) cases per 1,000 person‐years. An estimated 120.3 (SE, 16.9) individuals per 1,000 person‐years progressed from CIND to dementia. Over a 5.9‐year period, about 3.4 million individuals aged 72 and older in the United States developed incident dementia, of whom approximately 2.3 million developed AD, and about 637,000 developed VaD. Over this same period, almost 4.8 million individuals developed incident CIND. Interpretation: The incidence of CIND is greater than the incidence of dementia, and those with CIND are at high risk of progressing to dementia, making CIND a potentially valuable target for treatments aimed at slowing cognitive decline. ANN NEUROL 2011; | en_US |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.title | Incidence of dementia and cognitive impairment, not dementia in the united states | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Psychiatry | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Institute for Social Research, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationum | Departments of Psychiatry, Neurology, and Psychology, University of Michigan, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC | en_US |
dc.contributor.affiliationother | Veterans Affairs Center for Practice Management and Outcomes Research, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Medicine (Neurology), Duke University Medical Center, Durham, NC | en_US |
dc.contributor.affiliationother | Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Durham, NC | en_US |
dc.contributor.affiliationother | Center for Alzheimer's Care, Imaging, and Research, Department of Neurology, Center on Aging and the Brain Institute, University of Utah, Salt Lake City, UT | en_US |
dc.contributor.affiliationother | Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN | en_US |
dc.contributor.affiliationother | Colleges of Public Health and Medicine, University of Iowa, Iowa City, IA | en_US |
dc.contributor.affiliationother | 905 W. Main Street, Ste 25‐D, Box 41, Duke University Medical Center, Durham, NC 27701 | en_US |
dc.identifier.pmid | 21425187 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/86941/1/22362_ftp.pdf | |
dc.identifier.doi | 10.1002/ana.22362 | en_US |
dc.identifier.source | Annals of Neurology | en_US |
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dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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